Curriculum Vitae

HMS CURRICULUM VITAE

DATE PREPARED:  July 8, 2012

PART I: General Information

Name:	Kevin S. Hughes M.D., FACS Surgical Director, Breast Screening Co-Director, Avon Comprehensive    Breast Evaluation    Center
Office Address:	Massachusetts General Hospital 55 Fruit Street Surgical Oncology, Yawkey-7B Boston, MA  02114
Home Address:	13     Gloucester Street,  #4 Boston, MA  02115
Email:	kshughes@partners.org
Phone:	(617) 724-0048
FAX:	(617) 724-3895
Place of Birth:	Newark, NJ

Education:

1976	BA, Chemistry,DartmouthCollege
1979	MD,Dartmouth  MedicalSchool

Postdoctoral Training:

1979-1984	Resident, General Surgery,Mercy Hospital,Pittsburgh,PA
1984-1986	Fellow, Surgical Oncology, National Cancer Institute,Bethesda,MD

Licensure and Certification:

1985	American Board   of Surgery Certification
1988	Massachusetts  Medical License
1995	Re-certification, American Board of Surgery
2009	CITI Refresher course in the Protection of Human   Research Subjects
2006	Re-certification, American Board of Surgery

Academic Appointments:

1986-1987	Assistant Professor of Surgery,BrownUniversity
1987-1988	Assistant Professor of Surgery,University  ofCalifornia,Davis,CA
1989-1993	Clinical Instructor in Surgery, Harvard,MedicalSchool,  Boston,MA
1996-2000	Assistant Professor of Surgery,Tufts University,Boston,MA
2000-2008	Assistant Professor of Surgery,Harvard MedicalSchool  (HMS),Boston,MA
2008-	Associate Professor of Surgery,Harvard MedicalSchool  (HMS),Boston,MA

 

Hospital or Affiliated Institution Appointments:

1987-1988	Surgeon, Sacramento Medical Center,   Sacramento, CA
1991-2000	Senior Staff, Lahey Clinic,Burlington,MA
1995-2000	Cancer Liaison Physician,AmericanCollege  of Surgeons, Lahey Clinic, Burlington,MA
1997-2000	Associate Staff, Department of Surgery,SymmesHospital  andMedicalCenter,  Arlington,MA
2002-	Surgeon,Newton-Wellesley Hospital(NWH),Wellesley,MA
2000-	Associate Visiting Surgeon,Massachusetts GeneralHospital  (MGH),Boston,MA

 

Major Administrative Responsibilities:

1986-1987	Director, Division of Surgical Oncology,RogerWilliams GeneralHospital,  Providence,RI
1991-2000	Co-Director:Breast CancerTreatment Center, Lahey Clinic,Burlington,MA
1992-1993	Acting Chairman: Lahey Clinic Department of Research
1993-1995	Chairman:   Quality Breast Care Team, Lahey Clinic,Burlington,   MA
1994-2000	Director,   TheBreastCenter,   Lahey Clinic,Burlington,   MA
1994-2000	Co-Director, Women’sHealth Center,Clinic NorthShore,  Peabody,MA
1994-2000	Medical   Director, The Breast Cancer Risk Assessment Clinic,Lahey ClinicNorth Shore,Peabody,MA
2000-	Co-Director, Breast and Ovarian Cancer Genetics and   Risk Assessment Program, MGH,Boston,   MA
2001-	Co-Director,Avon ComprehensiveBreast EvaluationCenter,   MGH,Boston,MA
2006-	Medical Director,Bermuda  Cancer Genetics and Risk Assessment Clinic

Major Committee Assignments:

Hospital
1989-2000	Cancer committee,LaheyClinic Medical  Center
1992-1993	Cancer  CenterTask Force,   Lahey Clinic
1992-1993	Chairman, Research Policy Committee, Lahey Clinic
1992-1993	Education Executive Committee, Lahey Clinic
1992-1993	Research Fellow Review Committee, Lahey Clinic
1992-1993	Dana Fellow Review Committee, Lahey Clinic
1992-1993	Acting Chairman, Institutional review Board, Lahey Clinic
1992-1994	Chairman, Breast Subcommittee of the Clinical Effectiveness Committee, Lahey Clinic
1994-2000	Operating Room Committee,LaheyClinic  NorthShore
1996-1998	Co-Champion, Accelerating Clinical Improvement Team   for Breast Cancer Care, Lahey Clinic
1998-1999	Cancer  CenterPlanning   Committee, Lahey Clinic
1998-1999	Women’s   Health Task Force, Member, Lahey Clinic
1998-2000	Chairman,   Genetics Advisory Board, Lahey Clinic
2001-2005	Longitudinal Medical Record Steering Committee, MGH
2002-2005	Specialty   Specific OR Team-Surgical Oncology
2002-2005	BreastCenterCommittee,Newton WellesleyHospital
2002-2010	Longitudinal Medical Record Clinician Working Group
2007-	Privacy and Confidentiality Committee, MGH
2007-2010	Partners   Healthcare Personalized Medicine Clinical Decision Support Roadmap

Regional: 1993-1994 Massachusetts Department of Public Health Breast Cancer Quality Assurance Task Force National: 1988-1989 Professional      Education Committee, American Cancer Society,SacramentoCA 1988 Special Review Committee, Diagnostic Imaging Trial,     National Cancer Institute. 1988 Special Review Committee of RFA National     Collaborative Diagnostic Imaging Trial, National Cancer Institute 1994- National Consortium of Breast Centers, Inc.          1994-1998  Chairperson,BreastCenterRegistry Committee          1995-              Trustee-at-Large          1996-2002  Vice President      2005-2007  President Elect      2005-2007  Chairman Program Committee      2007-2009  President 2004- HL7 Clinical Genomics Special Interest Group      2007-2012        Co-Chair 2007-2010 American Society of Breast Surgeons Database     Committee 2007- Information Technology and Outcomes Committee,     National Accreditation Program for Breast Centers     2012-              Vice-Chair 2009-2012 American Society of Clinical Oncology, National     Cancer Prevention Committee      2009-2012        Chair, Genetics Subcommittee 2010- American Society of Clinical Oncology, Electronic     Health Records Workgroup

Professional Societies:

1981-	American Medical Association, Member
1982-1989	American  Collegeof Surgeons,   Associate Fellow
	1989 Fellow
	1989-1994   Cancer Committee,Massachusetts  Chapter
1987-	American Society of Clinical Oncology, Member
1987-	National Consortium of Breast Cancer Centers
1988-1991	American Society ofColonand Rectal Surgeons, Member
1990-2000	New EnglandCancer   Society, Member
1991-	Society of Surgical Oncology, Member
1993-1995	Association of Community Cancer Centers, Member
1993-	Boston  Surgical Society. Member
1995-	National Institutes of Health Alumni Association,   Member
1996-2007	New EnglandSurgical   Society, Member
2001-	American Society of Breast Diseases, Member
2001-	MGH Surgical Society, Member

Community Service Related to Professional Work:

	1992-2002	Scientific   Advisory Board for Continuing Medical EducationValleylab,   Inc.,Boulder,CO
	1996-1997	Chairman, Breast Cancer   Medical Advisory Board, OncorMed, Inc.,Gaithersburg,   MD
	1999-2001	Medical Advisory Board,   Assurance Medical,Hopkinton,   MA
	1999-2002	Scientific Advisory Board, Imagyn, Inc.,Irvine,CA

Editorial Boards:

	2006	Surgery, ad   hoc reviewer
	2006	Menopause   Journal, ad hoc reviewer
	2007	Cancer, ad   hoc reviewer
	2007	Drugs and Aging,   ad hoc reviewer
	2008	Breast Cancer   Research and Treatment, ad hoc reviewer
	2008	New England   Journal of Medicine, ad hoc reviewer
	2008	BMC Women’s   Health, ad hoc reviewer
	2008	The Journal of   Breast Health, ad hoc reviewer (international)
	2008	Breast Cancer   Research and Treatment, ad hoc reviewer
	2011	The Journal of   Breast Health, ad hoc reviewer
	2011	Genetics in   Medicine, ad hoc reviewer
	2012	Associate Editor, Breast   Cancer Research and Treatment

 

Awards and Honors:

	1973	National Merit Scholar
	1982	Laboratory Research Award, Southwestern Pennsylvania   Chapter,American  Collegeof Surgeons
	1983	Laboratory Research Award, Southwestern Pennsylvania   Chapter,American  Collegeof Surgeons
	1995	Proffered Paper Award, Annual Meeting, American   Society of Breast Disease
	2001	Sixth Annual Partners in Excellence Award,AvonBreast Cancer Project
	2006-	Castle Connolly Medical LimitedAmerica’s Top Doctors Award
	2006-	Castle Connolly Medical Limited Best Doctors for   Cancer
	2008-	Boston Magazine’sBoston’s Best Doctors, Surgery
	2010	The Global Directory of Who’s Who, Boston Top Doctor
	2010	Guide toAmerica’s Top Surgeons, Consumers’   Research Council of America
	2011	Boston  Super Doctors, Key Professional Media, Incorporated
	2011	Castle Connolly Medical Limited America’s Top Doctors   for Cancer Award
	2011	The Global Directory of Who’s Who, Boston Top Doctor

 

Part II: Research, Teaching, and Clinical Contributions

A. Narrative Report of Research, Teaching, and Clinical Contributions

At the MGH Department of Surgical Oncology, my practice involves the screening, diagnosis, and management of breast cancer and hereditary susceptibility to breast and ovarian cancer. I work closely with multiple specialties in my role as Co-Director of theAvonComprehensiveBreastEvaluationCenterand the Surgical Director of the Breast and Ovarian Cancer Genetics and Risk Assessment Program. Additionally, I serve as the Medical Director of the Bermuda Cancer Genetics Risk Assessment Program.

My first major research effort was to work collaboratively with 24 institutions world wide to establish a single centralized database of liver resections for metastatic colorectal cancer information.  Our findings set the standard indications for liver resection.

In the late 1980s, my focus shifted to the multidisciplinary care of breast disease, working for the widespread implementation of this approach through my writings and lectures, and serving as the 2006 and 2007 Program Chair for the National Consortium of Breast Centers, and now as its President.

My research focus is now the identification and management of women at high risk for breast and ovarian cancer.  I established theLaheyClinicRiskAssessmentCenterin 1995 (Recognized by the Oncology Round Table as a model risk clinic), and instituted genetic testing at that institution.

We have shown that the current methods of identification are grossly inefficient, and that most patients are not identified until after they develop cancer.  We have also shown that current approaches to management lack the ability to be successful at a large scale.

To solve these problems, I have organized the development of an open-source Tablet PC-based system that efficiently collects risk information, and shares data betweendepartments, thus greatly decreasing the time and resources needed to manage individuals.  This system is in use at multiple centers throughout the country.

On a national level, I served as the principal investigator of a Breast Cancer Cooperative Group trial that changed medical practice by showing that radiation is not always necessary for the woman over age 70.

I Co-Chair the Clinical Genomics Special Interest Group of HL7. We developed the national standard (ANSI) for the transmission of family history information between electronic medical records.  This has also been accepted as the standard for Clinical decision Support by Healthcare Information Technology Standards Panel (HITSP)

At an international level, we are using this system to identify every person who carries a BRCA1 or BRCA2 mutation onBermuda. I plan to develop a better understanding of this gene at the population level while simultaneously improving the management of these individuals.

I am actively involved in the training of surgical residents and breast surgery fellows.  I have co-authored at least one paper with each Fellow, providing guidance and mentorship.  I have instructed internal medicine and obstetrics-gynecology residents in the office practice of breast disease.  I spend a significant amount of time speaking about breast disease to medical students, physicians, nurses, and the lay public at Continuing Medical Education (CME) courses and invited presentations.  I have served as course director for multiple CME offerings as described in my CV.

In summary, we will set the standard for the identification and management of individuals at high risk for all hereditary diseases, and the transmission of that information between systems, departments, and institutions.

B. Funding Information

Past Research Funding:

	1987-2000	National Surgical Adjuvant Project for Breast and   Bowel Cancer 1989-2000, Principal Investigator,   Lahey Clinic
	1994-1996	Susan G. Komen Breast Cancer Foundation Boston Race for the Cure™ “Tumor marker analysis of ductal carcinoma in situ.”
	1996-1999	Susan G. Komen Breast Cancer foundation Boston Race for the Cure™ “Identification of women at high risk of developing breast cancer.”
	2000-2002	P.I. Ross Perot Foundation (PI) A study of hereditary   breast and ovarian cancer inBermuda
	2001-2002	P.I. Susan G. Komen Breast Cancer Foundation “Assessing Your Risk for Hereditary Breast and Ovarian Cancer” (Website)
	2001-2002	Salary support from the Breast Cancer SPORE for a database   programmer for one year to create a uniform data collection system for the   high-risk clinics at MGH, Dana Farber Cancer Institute, andBethIsrael  Hospital.
	2007-2008	Friends of the MGHCancer   Center Tablet Computer translation project.    Write and implement an upgrade to our Tablet PC software that allows   translation of the questions into Spanish, and develops a template for future   translation projects. (Dates open ended.)

Current Research Funding:

	1993-2019	National Cancer   Institute, Study Chairman, Cancer and Leukemia Group B.  Protocol   CALGB 9343. “Economic evaluation of lumpectomy, Tamoxifen, and irradiation of the breast   compared with lumpectomy plus Tamoxifen in women 70 years of age or older who   have carcinoma of the breast that is less than or equal to 4 cm. and   clinically negative nodes:  A Phase III   study” (Dates open ended.)
	2008-2011	RO1   1R01CA139118 Taghian (PI)    (Taghian)
		NIH
		TITLE:  Early Identification & Treatment of   Lymphedema in Women with Breast Cancer: Evaluation of Early Use Compression   & Its Impact on Quality of Life & Function.
		GOAL:  Evaluate the early of use of early   intervention as well as the impact on function and quality of life due   to mild and moderate volume lymphedema in women with breast cancer.
		ROLE:  Consultant (5%)
	2009-2011	CFDA 93.110/HRSA   09-140 (McInerney)
		TITLE:  Family History, Prenatal Care, and Women’s   Health: Development of a Family History Tool and Educational Materials for   Health Professionals and the Public
		GOAL:  To develop a family history collection   system for the prenatal visit with Clinical Decision support to identify   those at need of genetic counseling and testing
		Role:  Co-PI (10%)
	2009-2011	NIH Challenge Grant (Haas)
		TITLE:  Integrating and Interpreting Patient   -Generated Family Health History From E.H.R. Entry Portals.
		GOAL:  To develop a method to allow patient entry   of family history with uploading into the her
		ROLE:  Consultant (5% time)

C. Report of Current Research Activities

     Prospective Clinical Trials

	1989-1991	Intraoperative radio-Immunodetection of colorectal   metastases using an intraoperative gamma detection probe, Lahey Clinic, P.I.
	1990-	A comparison of lumpectomy plus Tamoxifen with and   without radiotherapy in women 70 years of age or older who have clinical   stage I, ER+ breast carcinoma, Study Chairman for National Study
	1993-1995	CEA scan for the detection of axillary metastases from   breast cancer, Lahey Clinic, P.I.
	1995-1997	Biofield electrophysiology study of breast lesions,   Lahey Clinic P.I.
	1996-1998	Assurance Medical pressure sensing study of breast   lesions, Lahey Clinic, P.I.
	1996-1998	Study of BRCA1 and BRCA2 Mutations in the Ashkenazi   Population, Lahey Clinic, P.I.
	1997-2000	Computerized thermographic imaging of breast, lesions,   Lahey Clinic, P.I.
	1998-2002	The GRACE Protocol, Lahey Clinic, P.I.
	2002-2004	Computerized thermographic imaging of breast. P.I.
	2003-2006	Measuring the Quality of Decisions in Breast Cancer,   American Cancer Society.
	2005-2006	A study of the firmness and elasticity of breast   masses, Medical Tactile Incorporated
	2006-	Identification of women at high risk for hereditary   breast/ovarian cancer syndrome using high through-put history collection:   rationale and implementation.
	2008-	The use of Natural Language Processing Software to   convert free text pathology reports to structured data
	2009-	A multi-institutional study of the natural history of   high risk breast lesions (Borderline DCIS, LCIS, ADH, ALH) using Natural   Language Processing (MGH, BWH, NWH, Faulkner)

 

D. Report of Teaching

1. Local contributions

	a. Harvard Medical School  – Medical School   Students
	2001	Introduction to Clinical Medicine, HMS
		contact time Preceptor 1 student each week 2 hours/week for 6weeks

	b. Graduate    Medical School   Courses
	2001-2006	Resident Breast Clinic, MGH
		contact time Preceptor 2 to 5 surgical residents each week 12 hours/month
	2000-	Internal Medicine Residency Breast Clinic, MGH
		contact time Preceptor 1 resident each week 12 hours/month
	2007-	Surgical Rotation Medical student Breast Clinic
		contact time Preceptor 1 medical student each week 12 hours/month

	c. Local Invited   Presentations
	Grand Rounds
	2001	Surgery, “Hereditary breast/ovarian cancer syndrome:   Clinical aspects,” MGH,Boston,   MA
	2001	Gynecology, “Hereditary breast/ovarian cancer   syndrome: What the gynecologist needs to know,” MGH,Boston,MA
	2002	Surgery, “Hereditary Breast/Ovarian Cancer Syndrome,”NewtonWellesley Hospital,Newton,MA
	2002	Gynecology Rounds, “Management of breast lumps and   abnormal mammograms,” MGH,Boston,   MA
	2002	Surgical Grand Rounds, “Hereditary Breast/Ovarian   Cancer Syndrome,”NewtonWellesleyHospital,  Newton,MA
	2005	Chiefs rounds,   Management of Benign Breast Problems, MGH,Boston,MA
	2007	“Genetic   Testing for Inherited Cancers”,Cambridge,   MA
	2010	Grand Rounds, “Identification of Women at High Risk of   Hereditary Breast/Ovarian Cancer”.  St   Elizabeth’s Hospital,Brighton,   MA.
	2010	Geriatric Grand Rounds.  “Breast Cancer in Older Women”.  MGH,Boston,   MA.
	2011	Grand Rounds – “Overview of   why testing is important to reduce risk of second cancers & who is   appropriate to test”.  St.   Elizabeth’s Hospital,Brighton,   MA.
	2012	Geriatric Core Curriculum Grand Rounds, “Breast Cancer   in the Elderly”.  MGH,Boston,MA.

	Local Invited   Presentations
	2001	Quarterly Seminar “Management of the high risk patient,”   Mount Auburn Hospital,Cambridge,   MA
	2001	Quarterly Seminar “Surgical management of breast   cancer,” Mount Auburn Hospital,Cambridge,   MA
	2001	Dana Farber Partners Breast Conference “Breast cancer in   the elderly,”Boston,MA
	2001	MGH Breast Conference “Breast cancer in the elderly,”Boston,MA
	2002	Chelsea Health Center Medical Group Meeting,   Management of Common Breast Problems,Chelsea,   MA
	2002	3rd Annual “Partners Physicians Day,” “Breast Cancer:   Issues and Controversies,”Boston,   MA
	2003	Genetic Testing for Breast Cancer, Vincent Symposium,   Boston, MA Given to members of the Vincent Society, donors to the obstetrics   program at MGH, and the lay public.
	2004	Large Scale Identification of Women at High Risk of   Hereditary Breast and Ovarian Cancer, Partners Informatics Research Seminar,Wellesley,MA
	2004	Breast Cancer in the Elderly,Boston  Surgical Society,Boston,   MA
	2005	Radiation Therapy is Not Always Needed After Breast   Conservation Debate, 11th Annual Perspectives in Breast Cancer,Boston,MA
	2005	Harvard Breast Conference Debate: Radiation Therapy is   Not Always Needed After Breast Conservation,Boston,MA
	2006	Management of Patients with Positive Sentinel Nodes,   12th Annual Perspectives in Breast Cancer,Boston,MA
	2006	Options for Breast Cancer Care in the Elderly,   Advances in Cancer Management for the Surgeon,Boston,MA
	2006	Determining If Your Patient is Truly at High Risk for   Developing Breast Cancer, Advances in Cancer Management for the Surgeon,Boston,MA
	2007	Advances in Cancer Management “Prevention and Risk   Stratification”.Boston,MA(A CME course offered by Surgical   Oncology at MGH, to attending physicians.)
	2008	Nuts and Bolts of Genetics and Genetic Research for   Research Nurses and Study Coordinators. “Open Source Software Package.”Boston,MA  (An MGH seminar for researchers in Genetics)
	2008	Advances in Cancer Management for theSurgeon-Harvard  MedicalSchool  CME Course.  “Identification and   Management of Women at High Risk of Breast Cancer.” Boston,   MA
	2008	CIRD Informatics Seminar.    “Improving the Use of Family History in the Electronic Health Record:   A Means to Improve the Identification and Management of Patients at High Risk   of Hereditary Disease.” Boston,MA
	2009	Advances in Cancer Management for the Surgeon. “Identification and Management of Women at   High Risk for Breast Cancer.”Boston,   MA.
	2010	New Horizons Moderator, Session II.  “PRE-Invasive Disease, Breast Cancer:   Current Controversies”. Boston,   MA.
	2010	American Society of Clinical Oncology Meeting.  “Breast Cancer: Local Therapy”. Boston,   MA
	2010	Boston  Veterans Administration Oncology Speaker Series.  “Overview of why   testing is important to reduce risk of second cancers & who is   appropriate to test”. Boston,MA
	2010	Lawrence  GeneralHospital  CommonwealthHematology   Oncology Lecture.  “Update in Hereditary   Breast and Ovarian Cancer: Identifying and Managing High Risk Patients”. Lawrence,   MA
	2011	Massachusetts General Hospital Massachusetts General   Medical Group Speaker Invitation.    “Breast Cancer in Men and Gynecomastia”. Boston,   MA
	2011	Massachusetts General Hospital Advances in Cancer   Management Parallel Workshop Sessions.    “Identification and Management of Women at High Risk for Breast   Cancer”. Boston,MA
	2012	Lecture toMassachusetts  General Hospital Internal Medicine Junior and Senior Residents on ACR.  “Breast Disorders”. Boston,   MA

	d.	Continuing   Medical Education
	2002	‘Two Ends of the Breast Cancer Spectrum: The DCIS   Epidemic and Advanced Disease Treatment Challenges”, and “Local Therapy for   DCIS: Surgery and Radiation Issues.”  Harvard   Course,Boston,MA
	2003	“Breast Cancer Care in the Elderly”. Harvard MedicalSchool  Continuing Education Course,Cambridge,   MA
	2004	“Breast Cancer – High Risk Patients”.  Partners Update in General Internal   Medicine for Subspecialists (a CME course),Boston, MA
	2009	“In Hospital Conferences”. Harvard MedicalSchool  Continuing Medical Education,Cambridge,   MA
	2010	“In Hospital Conferences”. Harvard MedicalSchool  Continuing Medical Education,Cambridge,   MA
	2011	The 16th Annual Multidisciplinary Symposium   on Breast Disease.  TheUniversity ofFlorida  College ofMedicine. Amelia   Island, FL
	2011	“Hereditary Breast and Ovarian Cancer”. Keck Schoolof Medicine of theUniversityofSouthern    California,Las     Vegas,NV
	2011	“6th Annual Breast Cancer Symposium”.  Wake Forest University Bridger Field House,   WinstonSalem,   NC

g. Advisees and Trainees

Duration	Name	Training Type
1992-1993	Gasan     Mackarem,MD	Advisor, Robert Wise Fellowship in Breast Surgery,   Lahey Clinic
1993-1994	Mauricio     Camus,MD	Advisor, Robert Wise Fellowship in Breast Surgery,   Lahey Clinic
1993-1994	Mega Joshi,   MD	Advisor, Robert Wise Fellowship in Breast Surgery,   Lahey Clinic
1994-1996	Gasan     Mackarem,MD	Advisor, Robert Wise Fellowship in Breast Surgery,   Lahey Clinic
2005-2006	Adrienne O’Connell	Master’s Thesis Advisor, Boston University School of   Health Administration
2006-2010	Brian Drohan	Mentor for Ph.D candidate, UMass,Lowell,MA
2006-2008	John Sharko	Mentor for Ph.D candidate UMass,Lowell,MA

 

 

2. Regional, National, and International Contributions

	National Grand   Rounds
	2001	HackensackUniversityMedical CenterGrand Rounds, “Management of   Recurrent Breast Cancer,”Hackensack,   NJ
	2002	Riverside Hospital Grand Rounds, “Approaches to the   Diagnosis of Breast Cancer using Various Biopsy Techniques,”Valhalla,NY
	2004	Breast Cancer in the Elderly,Yale CancerCenter  Grand Rounds,New Haven,CT
	2010	Legacy  GoodSamaritan  MedicalCenter  Grand Rounds.  “How to identify   and Manage patients with Hereditary Breast and Ovarian Cancer”. Portland,   Oregon.
	2010	Cancer Institute ofNew JerseyCancer  CenterGrand Rounds Seminar.  “Hereditary Breast Cancer”. New     Brunswick,NJ.
	International Grand   Rounds
	2001	KingEdward VIIHospital  Grand Rounds “Hereditary Breast/Ovarian Cancer in Bermuda,”Bermuda

	Regional Invited   Presentations
	2001		UniversityofMassachusetts,Boston,MA,   Graduate Program in Computer Science
	2001		SouthernMaine MedicalCenter  Grand Rounds, Sentinel Node Biopsy for Breast Cancer,”Kennebunkport,ME
	2001		Nurse Practitioner Association for Continuing   Education  “Screening, diagnosis and   management of breast cancer,”Newport,   RI
	2002		SturdyMemorialHospital,   “Hereditary Breast/Ovarian Cancer Syndrome,”Attleboro,MA
	2003-2005		Preceptor,University  ofMassachusetts,Boston,MA,   Graduate Program in Computer Science
	2003		Challenges in Breast Cancer Management, Mammography   Seminar and Panel,Burlington,   MA
	2004		Breast Cancer in Older Women, NPACE,Hyannis,MA
	2004		Management of Breast Problems of the Primary Care   Physician,GeigerGibsonHealth Center,Dorchester,MA
	2004		Breast Cancer in Older Women, St. Anne’s Hospital,Fall River,MA
	2004		Surgical Advances in Breast Cancer Management, St.   Elizabeth’s Hospital Cancer Course,Boston,   MA
	2005		Treatment of Breast Cancer in the Elderly, New   Direction in Breast Cancer Care Symposium,Elliott Hospital,Bedford,MA
	2005		Breast Conservation and Tamoxifen vs. Radiation,   Update in Breast Cancer,Manchester,   NH
	2005		Proposal for a Newton Wellesley Hospital Project:  Large Scale Identification of Women at High   Risk of Hereditary Breast and Ovarian Cancer, NWH President’s Council,   Newton, MA
	2005		Genetic Testing for BRCA1 and BRCA2, St. Luke’s   Hospital Grand Rounds, New Bedford, MA
	2005		Proposal for a Newton Wellesley Hospital Project:  Large Scale Identification of Women at High   Risk of Hereditary Breast and Ovarian Cancer, NWH President’s Council,   Newton, MA
	2005		Hereditary Breast and Ovarian Cancer:  Identification of Women at Risk,CharltonMemorial Hospital,Fall River,MA
	2006		Gave opinion on article: “New Gene Tied to Added   Breast Cancer,” ABC News Now’s “Healthy Life,”Needham,MA
	2006		Hereditary Breast and Ovarian Cancer: Identification   of Women at Risk,Charlton Memorial     Hospital,MA
	2006		Large Scale Identification of High Risk Women, NWH   Leadership Project,Newton,   MA
	2007		Review of the San Antonio Breast Cancer Symposium “Breast   Cancer in the Elderly,” Providence,RI
	2007		Rhode IslandSurgical   SocietyRhode IslandHereditary in Cancer   Management “Genetics (Genomics) in Surgical Management of Breast Cancer,”Providence,RI
	2007		Innovations in Gynecology “Breast and Ovarian Cancer   Screening,”Cambridge,MA
	2008		Commentary on the Use of Radiation After Breast   Conservation, Cambridge HospitalTumor Board,Cambridge,MA
	2008		Women’s Health Annual Visit. “Breast and Ovarian Cancer,”Cambridge,MA.
	2008		Stamford  Hospital.  “Industrial Level Identification of Women   at High Risk of Breast Cancer: Reducing the Incidence, Morbidity and   Mortality of Breast and Ovarian Cancer,”Stamford,CT
	2008		Jordan  Hospital.  “Industrial Level Identification of Women   at High Risk of Breast Cancer: Reducing the Incidence, Morbidity and   Mortality of Breast and Ovarian Cancer,”Plymouth,MA
	2008		TEC Summer Science Institute.  “Breast Cancer,”Dedham,MA
	2008		New England Regional Genetics Group Meeting.  “Assessing Risks for Families with   Inherited Cancers: An Introduction to a New System.” Portsmouth,   NH
	2009		Starr  CenterBreast Cancer   Symposium. “New Technology for Capturing Patient Information.” Massachusetts    GeneralHospital,Boston,MA
	2009		Medical Staff Education Program.  “Preventing Breast Cancer.” Exeter     Hospital,NH.
	2010		BioIT World Conference & Expo 2010.  “A Patient Entered Family Health History   Tool to Initiate Guidelines for Prenatal Genetic Testing Using Clinical   Decision Support (CDS)”. Boston,MA.
	2010		Partners Healthcare 7th Annual IS Technology   Summit 2010.  “Decreasing Clinician workload   while increasing quality using Clinical Decision Support and patient entered   data:  Our experience in identifying   and managing Hereditary Breast/Ovarian Cancer Syndrome.”Needham,MA.
	2010		Lawrence  GeneralHospital  Tumor Board Lecture.  “Hereditary Breast   and Ovarian Cancer”. Lawrence,MA.
	2010		Health Level 7 Annual Plenary Meeting Lecture. “Future of   healthcare using genomics as a key tool”. Cambridge,   MA.
	2012		Dana Farber Cancer Institute/HarvardCancer  CenterRisk Prediction   Workshop. “Integrating patient entered data and Clinical Decision Support   into the clinic workflow using Tablet technology”.Boston,MA.
	National Invited Presentations
	2001		National Consortium of Breast Centers Annual Meeting   “Managing the patient with an abnormal mammogram,”Las Vegas,NV
	2001		Multidisciplinary Breast Conference “Biopsy options for   the patient with an abnormal mammogram,” Magee Women’s Hospital,Pittsburgh,PA
	2002		American Society of Breast Surgeons Third Annual Meeting,   “Breast Cancer: Prevention and Risk Assessment,”Boston,MA
	2002		Society for Women’s Imaging, “Thermal Imaging in the   Diagnosis of Breast Cancer,”Boston,   MA
	2002		Riverside Hospital Grand Rounds, “Approaches to the   Diagnosis of Breast Cancer using Various Biopsy Techniques,”Valhalla,NY
	2003		Understanding Hereditary Risks for Familial Breast   Cancer,DallasAmerican Board of Surgery,Dallas,TX
	2004		Breast Cancer in the Elderly, New York Metropolitan   Cancer Group, Inc Annual Breast Cancer Symposium,New York,NY
	2004		Large Scale Identification of Women at High Risk of   Hereditary Breast and Ovarian Cancer, Myriad Genetics: Genetic Counselor   Course,Salt Lake City,UT
	2005		The Use of the HL7 Standard to Promote Interoperability   in Family History Software, CDC Conference on Genomics and Public Health,   Atlanta, GA
	2005		Commentary on the Use of Radiation After Breast   Conservation, ASTRO Annual Meeting, Denver, CO
	2005		Large Scale Identification of Women at High Risk of   Breast/Ovarian Cancer,TexasOncology   Retreat and Strategic Planning Meeting,Dallas,   TX
	2005		HL7 Working Group Meeting,Scottsdale,AZ
	2005		Large Scale Identification of Women at High Risk of   Hereditary Breast and Ovarian Cancer, National Consortium of Breast Centers,Las Vegas,NV
	2005		Organization of a High Risk Clinic, American Society   of Breast Surgeons,Los Angeles,   CA
	2005		Breast Cancer in the Elderly, American Society of   Breast Diseases,Las Vegas,   NV
	2006		Management of Hereditary Breast Cancer: How Many Women   Are At Risk for Hereditary Breast Cancer? NCBC,Las Vegas,NV
	2006		Radiation in the Elderly, NCBC,Las Vegas,NV
	2006		Lumpectomy Plus Tamoxifen with or without Irradiation   in Women 70 Years of Age or Older with Early Breast Cancer: A Report of   Further Follow-Up,San Antonio,   TX
	2007		17th Annual Interdisciplinary Breast Center   Conference “Large scale Identification of women at high risk of Breast   Cancer,”Las Vegas,NV
	2007		Hackensack University Medical Center Grand Rounds “Large   scaleIdentification of   women at high risk of Breast Cancer”.Hackensack,   NJ
	2007		American Society of Clinical Oncology “Management of   the Frail Elderly with Breast Cancer-Alternatives in Surgery, Systematic   Therapy and Radiation Therapy,”Chicago,   IL
	2007		National Comprehensive Cancer Network Breast Cancer in   the Older Woman Task Force “Management of the Axilla in the Elderly Breast   Cancer Patient,”Philadelphia,   PA
	2007		Genetics Conference “The Use of Family History in   Identifying High Risk Patients,”Salt     Lake City,UT
	2007		Genetics Conference “Patient Entered Family History in   the High Risk Cancer Setting,”Salt     Lake City,UT
	2007		Women’s Health Annual Visit Full-Day Symposium “Breast   and Ovarian Cancer Screening,”Dearborn,   MI
	2007		San AntonioCancer   Symposium “Identifying High-Risk Postmenopausal Women as Candidates for   Raloxifene Therapy in a Surgical Practice,”San Antonio,TX
	2007		Geriatric Oncology Consortium’s Fifth Annual Meeting   “Advancing Cancer Care in Elderly: Clinical Options in Breast and Prostate   Cancer,”WashingtonDC
	2008		Oncology Hematology Care “Breast Cancer,”Cincinnati,OH
	2008		The 13th Annual Multidisciplinary Symposium   on Breast Disease. “What Everyone Should Know About Breast Health,”AmeliaIsland, FL
	2008		The 35th Annual Symposium For the Breast Cancer   Specialist. “Breast Cancer in the Elderly: A Selected Approach for a Unique   Population,”New York,NY
	2008		18th Annual National InterdisciplinaryBreastCenter Conference. “Identification and   Management of the Woman at High Risk for Hereditary Breast and Ovarian   Cancer,” Las Vegas,NV
	2008		18th Annual National InterdisciplinaryBreastCenter Conference. “Intro/Opening   General Membership Meeting.”Las     Vegas,NV
	2008		Omnia Education.  “Breast   and Ovarian Cancer: Screening and Prevention,”Chicago,IL
	2008		9th Annual Meeting of American Society of   Breast Surgeons. “Saving Time and Work: Patient Data Entry.”New York City,NY
	2008		Innovations in Gynecology CME Symposium. “ Breast and   Ovarian Cancer Screening,”Chicago,   IL
	2008		VA Genomic Medicine Advisory Committee Meeting.  “Large Scale Identification of Women at   High Risk of Hereditary Breast Ovarian Cancer: Clinical Decision Support,   Interoperability, and the Potential of the Electronic Health Record,”WashingtonDC
	2008		St. Vincent’sMedicalCenter.  “Genetic Testing for Hereditary Breast and   Ovarian Cancer.” South Bend,IN
	2008		North American Menopause Society (NAMS) 19th Annual   Meeting-Optimal Clinical Meeting. “Breast Cancer: Scope of Problem and Risk   Factor Identification of Women at High Risk of Breast Cancer.” Orlando,   FL
	2008		Innovations in Gynecology.  “Recent Developments and Guidelines for   Colorectal Cancer Screening.” Boston,MA
	2008		MD Advantage Insurance.  “Identification and Management of   Hereditary Cancer Syndromes, Using Breast/Ovarian Cancer Syndrome as the Main   Example.  Using Genetics to Save   Lives.” Lawrenceville,NJ
	2009		‘Using Standards to Gain Interoperability with the   Surgeon General’s Family History Website’.    Health Level 7 Conference. Orlando,FL
	2009		Identification and Management of Women at High Risk of   Hereditary Cancer. Lutheran GeneralHospital. St.     Louis,MO  (trip 1/22-23)
	2009		Genetic Counselor Graduate Course, Invited   Lecturer.  Identification and   Management of Women at High Risk of Hereditary Cancer. Brandeis University,Waltham,MA  (trip 3/11)
	2009		19th Annual National InterdisciplinaryBreastCenter Conference. Las     Vegas,NV
	2009		IBM EHR Seminar, Family Health Pedigree. Washington,   DC  (trip 3/20)
	2009		Health Information and Management Systems   Society.  Interoperability of the Surgeon   General’s Family History Collection System and the Electronic Health   Record  Chicago, IL
	2009		Fayetteville  Radiology Lecture Series, Identification and Management of Women at High Risk   of Hereditary Cancer:  Using Genetics   to Save Lives.Fayetteville,   AR
	2009		American Society of Breast Surgeons 10th   Annual Meeting.  New Approaches to   Developing a Genetics Risk Assessment Program. San     Diego,CA
	2009		Society of Surgical Oncology.  Bringing genetic testing into the   Mainstream. Phoenix,Arizona
	2009		MD Advantage Insurance Seminar.  A Primer on Genetic Cancer:  Understanding Genetics to Decrease   Liability. Princeton,NJ
	2009		Clinical Society of Trinitas. CME Activity.   Identification and Management of Women at High Risk of Hereditary   Cancer:  Using Genetics to Save   Lives. Newark,NJ
	2009		Breast Conference, “Identification of Women at High   Risk for Hereditary Breast/Ovarian Cancer Syndrome.” Backus Hospital,Norwich,CT
	2009		Columbia  UniversityMedical  CenterBreast   Conference.  “Identification and   Management of Women at High Risk of Hereditary Breast Cancer.” New     York,NY
	2009		CancerSummit:   Lung, Head & Neck, Breast, and Gastrointestinal and Colorectal Cancers.   “Management of Women at High Risk of Breast Cancer.”Hilton Head Island,South Carolina.
	2009		NIH  Stateof Science   Conference: Family History and Improving Health.  “Health   IT-Based Strategies for Studying the se of Family History in Primary   Care”. Bethesda,MD
	2009		ACIs National Conference on Comprehensive Breast   Centers of Excellence.  “Using Genetics   to Save Lives: The Identification and Management of Women at High Risk of   Hereditary Cancer:Baltimore,   MD
	2009		Ohio  Health Dinner Lecture Series– Breast Health Education.  “Identification and management of women at   high risk of hereditary cancer:  Using genetics to save lives” Columbus,   OH
	2010		HL7, Personalized Medicine and the Personal Health   Record/HER.  “The EHR and Family   History in the World of Personalized Medicine”. Phoenix,   AZ.
	2010		Aurora Breast MRI Society Annual Meeting.  “Understanding ACS Guidelines: identifying   high risk patients using models and putting into practice”. Las     Vegas,NV.
	2010		American  Collegeof Surgeons   Chapter Meeting.  “Identification and   management of women at high risk of hereditary cancer:  Using genetics   to save lives” San Juan, PR
	2010		Health Information Management Systems Society. Atlanta,   GA
	2010		20th National InterdisciplinaryBreastCenter Conference.  “Hereditary Breast Cancer: The Magnitude of   the Problem”. Las Vegas,NV
	2010		Maine     GeneralMedicalCenterOncology Rounds, “Industrial   Strength Identification of Women at High Risk of Hereditary Breast Ovarian   Cancer”. Augusta,Maine
	2010		Breast  SymposiumBreast  Center.  “Hereditary Breast Cancer: The Magnitude of   the Problem”. Omaha,Nebraska
	2010		Sommer Memorial Lectures/OHSUSchoolofMedicine  Alumni Scientific Meeting.  “Memory   Based Medicine vs Clinical Decision Support: How Do You Want Your Loved Ones   Cared For”. Portland,OR
	2010		GeneticAlliance  Annual Conference.  “Family history,   prenatal care, and novel health information technology:  a collaborative risk assessment and   educational tool for health professionals and the public.”Washington,DC
	2010		Robert  WoodJohnson  Hospital.  Speaker at Mama Mare Benefit, “An   Introduction to a Personalized Health Record (PHR) for Women with BRCA   Mutations”. New Brunswick,NJ.
	2010		St. Peter’sBreast  Center. “Reasons for and   issues related to patient identification, counseling and testing in the   breast center setting”. Albany,NY
	2010		University   ofChicagoMonthly   Breast Cancer Seminar.  “Identification   and management of women at high risk of hereditary cancer:  An industrial approach using computerized   clinical decision support”. Chicago,IL
	2011		16th Annual Multidisciplinary Symposium on Breast   Disease.  “Industrial Strength   Identification and Management of Women at High Risk of Hereditary Breast   Cancer”. Amelia Island,Florida
	2011		21st National InterdisciplinaryBreastCenter  Conference.  “Using Information   Technology to Identify & Reduce Risk in Hereditary Cancer”. Las     Vegas,NV
	2011		American Society of Breast Surgeons 12th   Annual Meeting.  “Breast Electronic   Medical Record”, “Hereditary Breast Cancer”.   Washington,DC
	2011		ClevelandClinic Ob/Gyn   andBreastCenterTalk.  “Hereditary Breast and Ovarian   Cancer”. Cleveland,Ohio.
	2011		Saint Barnabas Health Care System Comprehensive High   Risk Breast Cancer Evaluation Symposium.    “Industrial Strength Identification of Women at High Risk for   Hereditary Breast Ovarian Cancer Syndrome”.   Long Branch,New Jersey.
	2011		Florida Hospital Cancer Institute American Society of   Hematology and the American Society of Clinical Oncology Update.  “Breast Surgery:  Breast Cancer Risk”. Orlando,   FL.
	2011		Chemotherapy Foundation Oncology Symposium.  “Predictive and Prognostics Tools for   Electronic Health Records Web Applications”.   New York City,NY.
	2011		ASCO HIT/EHR Symposium.  “Beyond the Electronic Health Record – New   Health Information Technology”. Atlanta,GA
	2011		Endo-Surgery Institute Society of Surgical Oncology   Conference.  “Risk Assessment and   Reduction (Genetic Testing)”. Cincinnati,Ohio.
	2011		The 4th National Conference on Next   Generation Comprehensive Breast Centers of Excellence.  “Electronic Medical Record Implementation   Solutions:  Use of The Electronic Health   Record in TheBreast   Center”. Atlanta,   GA.
	2012		Hematology Oncology Today Breast Cancer Meeting.  “Risk Assessment and Individualized   Screening”. San Diego,CA
	2012		22nd Annual National InterdisciplinaryBreastCenterConference. “Clinical   Management According to Risk”.Las     Vegas,NV.
	2012		29th Miami Breast   Cancer Conference. “Using Computers to Increase Efficiency in a Breast   Oncology Practice”, “Electronic Health Records: Are You Ready?”, “Software   Program to Identify and Manage Women at High Risk”, “Is Post-Lumpectomy Radiation   Necessary in Older Patients?”.Miami,   FL.
	2012		Myriad Genetics, AmericanCollege of SurgeonsRhode Island  Chapter.  Genetic Risk Factor:  “High Risk Gene Profiles in Breast Cancer   Management BrCa I & II and other Issues”.   Warwick,RI.
	2012		American Society of Breast Surgeons. Breast Cancer:   Special Situations. “Breast Cancer in the Elderly”.Phoenix,AZ.
	Pending2012		Robert  H.Lurie  ComprehensiveCancer  Centerat the Lynn Sage   Breast Cancer Symposium. (Speaker).Chicago,   IL.
	International   Invited Presentations
	2001		4th UAE Cancer Conference “Molecular basis of   breast cancer,”Abu Dhabi,   United Arab Emirates   (UAE)
	2001		4th UAE Cancer Conference “Surgical management   of breast cancer,”Abu Dhabi,   UAE
	2001		4th UAE Cancer Conference “Screening and   diagnosis of breast cancer,”Abu     Dhabi, UAE
	2004		Hereditary Breast Cancer. Identification of High Risk   Women,VareseUpdate on Breast Cancer,Varese,Italy
	2004		Organization of aBreast Center,Varese  Update on Breast Cancer,Varese,   Italy
	2004		DCIS: Treatment Options,King HusseinCancer CenterOncology Conference,Amman,Jordan
	2004		Sentinel Node Biopsy,King HusseinCancer CenterOncology Conference,Amman,Jordan
	2004		“Hereditary Breast Cancer in Bermuda,”Hamilton,Bermuda,   given to the lay public.
	2005		Bermuda TB and Cancer Society Public Lecture on Hereditary   Cancer in Bermuda,Hamilton,Bermuda,   given to the lay public
	2005		Sentinel Node Biopsy for Breast Cancer, King Hussein   Cancer Center Course on Women’s Cancers,Amman,Jordan
	2006		Identification and Management of Women at High Risk of   Hereditary Breast and Ovarian Cancer, IISS Course: Breast Cancer and   Melanoma: Biology, Diagnosis and Therapy,Varese,Italy
	2006		Breast Cancer Treatment in the Elderly:   Individualizing Treatment, IISS Course: Breast Cancer and Melanoma: Biology,   Diagnosis and Therapy,Varese,   Italy
	2006		Neoadjuvant Chemotherapy in Breast Cancer, King   Hussein Cancer Center Course on Women’s Cancers,Amman,Jordan
	2006		Hereditary Breast and Ovarian Cancer, King Hussein   Cancer Center Course on Women’s Cancers,Amman,Jordan
	2007		Arab Medical Association Against Cancer “Breast Cancer   in the Elderly,”Amman,Jordan
	2007		Arab Medical Association Against Cancer “Surgical   challenges in the era of neoadjuvant therapy”.Amman,Jordan
	2008		Istanbul  Breast Cancer Conference and National Breast Cancer Consensus Meeting.  “ Hereditary Predisposition, Identifying   High Risk, Managing High Risk.: Istanbul,Turkey
	2008		Istanbul  Breast Cancer Conference and National Breast Cancer Consensus Meeting.  “Controversies in the Surgical Treatment of   LCIS and DCIS.” Istanbul,Turkey
	2010		International Symposium on Breast Cancer. “Breast imaging   and genetic testing for breast cancer diagnosis in women age 40 and younger.”   “Breast cancer in elderly women: dilemmas and issues.”Sao Paulo,Brazil.
	2011		1stPavia   Update on Breast Cancer.  “How to set   up a high risk clinic”, “Hereditary Disease, How Great a Burden and How Well   Are We Doing?” and “US Surgeon’s and women’s perspective of risk reduction   mastectomy”. Pavia,Italy
	2011		Melange Foundation Charitable Organization.  “Bermuda’s Genetic Link to Breast   Cancer”. Hamilton,  Bermuda.
	2011		3rd World Congress for the Advancement of   Surgery.  “Hereditary Breast Ovarian   Syndrome:  The Role of Risk Models and   Health Information Technology” and “Breast Cancer in the Elderly:  Is Radiation Necessary in Early   Cancer?” Jerusalem,Israel
	2011		IBM Haifa Research Lab Family Health History   Workshop.  “Exploration of Potential   Solutions to Data Collection and Clinical Decision Support for Family Health   History.  Haifa,Israel.
	2011		Annual Conference of the Israeli Association for Medical   Informatics.  “Creating theElectronic Health Record of the Future”.  TelAviv,   Israel.

	b. Professional and Educational Leadership
	1987	Course Director, Ultrasonic Liver Surgery:BrownUniversity,  Providence,RI
	1988	Course   Director, Ultrasonic Liver Surgery:University  ofCalifornia,Davis,CA
	1989	Course   Director, Ultrasonic Liver Surgery: Lahey Clinic,Burlington,MA  (Spring)
	1989	Course   Director, Ultrasonic Liver Surgery:LaceyClinicMedical Center,BurlingtonMA  (Fall)
	1990	Course   Director, Current Concepts in Hepatobiliary Surgery: Lahey Clinic,Burlington,MA
	1990	Course   Director, Current Concepts in Surgical Oncology,San Francisco,CA
	1991	Course   Director, Topics inColonand Breast Cancer   Treatment,Chicago,IL
	1996	Course Director, Hereditary Breast Cancer: An Update   for Clinicians,Washington,   D.C
	2004	Course Co-Director,Varese  Update on Breast Cancer,University  ofInsubria,Varese,Italy
	2006	Program Chairman, Annual Meeting of the National   Consortium of Breast Centers,Las     Vegas,NV
	2007	Program Co-Chairman, Annual Meeting of the National   Consortium of Breast Centers,Las     Vegas,NV
	2007	Course Director, Hereditary Breast Cancer for   Clinicians, Pre-Conference Seminar, National Consortium of Breast Centers,Las Vegas,NV
	2008	Course Director, Hereditary Breast Cancer for   Clinicians, Pre-Conference Seminar, National Consortium of Breast Centers,Las Vegas,NV
	2009	Course Director, Hereditary Breast Cancer for   Clinicians, Pre-Conference Seminar, National Consortium of Breast Centers,Las Vegas,NV
	2010	Course Director, Hereditary Breast Cancer for   Clinicians, Pre-Conference Seminar, National Consortium of Breast Centers,Las Vegas,NV
	2011	Course Director, Hereditary Breast Cancer for   Clinicians: 2011 Update, Pre-Conference Seminar, National Consortium of   Breast Centers,Las Vegas,   NV
	2011	Course Director, Half-Day Pre-Conference Symposium,   American Society Breast Surgeons,Washington,   DC.
	2012	Planning Committee, Hematology Oncology Today Breast   Cancer Meeting. San Diego,CA

 

E. Report of Clinical Activities

As previously described, I am a practicing physician actively involved in research and teaching.

Patient load

Each year I evaluate and manage approximately 900 new patients with breast problems, and perform close to 400 operations.

 

Clinical contributions

I have had a leadership role in the development of numerous breast centers (Brown University, 1987, University of California at Davis, 1988, Lahey Clinic Breast Cancer Treatment Center, 1990, Lahey Peabody Breast Center, 1995, Avon Center, MGH, 2000) and have consulted for numerous hospitals developing breast centers (Most recently, at Newton Wellesley Hospital).

I played an integral role in bringing risk assessment and genetic testing to the Lahey Clinic in 1995, founding the Lahey Breast Cancer Risk Assessment Clinic, and serving as Chairman, Lahey Clinic Genetics Advisory Board, where I lead the effort to develop the Lahey guidelines for genetic testing for breast and ovarian cancer susceptibility.

While I do not see patients atNewtonWellesleyHospital, I have worked in an administrative capacity to develop a collaborative effort between the NWH Breast Imaging service, theNWHAuerbachBreastCenter, and the Division of Surgical Oncology at MGH.  We have instituted a comprehensive approach to the large scale identification of women at risk for hereditary breast ovarian cancer, and begun to develop management strategies for these women.  We have installed and enhanced our open source software, which allows the industrial level collection of structured family history data with minimal resources.  To date (April, 2008), we have collected over 27,000 family histories, identified over 1000 women who are at high risk, and increased genetic testing five-fold at that institution.   We are now modifying the software for use in the colon cancer screening center to identify patients at risk for hereditary colon cancer.  We plan to produce a cardiac disease module, a diabetes module, and other cancer modules in the near future.

The open source software we developed (described above) will transform the approach to the identification and management of patients at high risk of hereditary diseases.  By allowing the collection of structured family history with minimal additional resources, and by making the management of high risk individuals more efficient, we hope to facilitate widespread risk identification and management.

InBermuda, I serve as the Medical Director of the Bermuda Cancer Genetics Risk Assessment Program.  Under the auspices of Partners International (which provides partial funding) and partial funding from the private insurance companies ofBermuda, I travel to the island quarterly to counsel high risk women, and to arrange genetic testing as appropriate.

I have worked closely with Dr. Bruce Chabner under the Avon Grant to develop and implement a system for the clinical breast care of the underserved population of theBostonarea.  This service has markedly improved the quality of breast care for these women, and has allowed them to have breast imaging, surgical consultation, and fine needle aspiration in a single facility, with a single visit.

Part III: Bibliography

Original Articles

1 Hughes KS, Marrangoni AG, Thompson DR, Turbiner E: Endotoxic     shock and its effects on hepatobiliary scanning in dogs. Radiology     1983;148(3):823-826. 2 Hughes KS, Marrangoni AG, Turbiner E:  Etiology of the obstructive pattern in     hepatobiliary imaging.  Nuclear     Medicine 1984;9(4):222-226. 3 Hughes KS, Marrangoni AG, Thompson DR, Turbiner E:  Intrahepatic cholestasis as a cause of     false-positive hepatobiliary scanning.      Current Surgery 1984;41(3):176-179. 4 Hughes KS, Kowalsky TE, Copeland CE, Marrangoni AG, Turbiner     E:  The effects of pressure and     hepatocellular damage in biliary tract obstruction.  Current Surgery 1984;41(4):227-229. 5 Hughes KS, Simon R, Songhorabodi S, Adson MA, Ilstrup DM,     Fortner JG, Maclean BJ, Foster JH, Daly JM, Fitzherbert D, Sugarbaker PH,     Iwatsuki S, Starzl T, Ramming KP, Longmire Jr. WP, O’Toole K, Petrelli NJ,     Herrera L, Cady B, McDermott W, Nimms T, Enker WE, Coppa GF, Blumgart LH,     Bradpiece H, Urist M, Aldrete JS, Schlag P, Hohenberger P, Steele Jr. G,     Hodgson WJ, Hardy TG, Harbora D, McPherson TA, Lim C, Dillon D, Happ R,     Ripepi P, Villella E, Rossi R, Remine SG, Oster M, Connolly DP, Abrams J,     Al-Jurf A, Hobbs KEF, Li MKW, Howard T, Lee E:  Resection of the liver for colorectal carcinoma     metastases: a multi-institutional study of patterns of recurrence.  Surgery 1986;100(2):278-284. 6 Lefor AT, Hughes KS,     Shiloni E, Steinberg SM, Vetto JT, Papa MZ, Sugarbaker PH, Chang AE:  Staging of patients with suspected     isolated colorectal liver metastases. Current Surgery 1987;44(4):308-310. 7 Lefor AT, Hughes     KS, Shiloni E, Steinberg SM, Vetto JT, Papa MZ, Sugarbaker PH, Chang     AE:  Intra-abdominal extrahepatic     disease in patients with colorectal hepatic metastases. Diseases of the Colon and Rectum     1988;31(2):100-103. A09 Lefor 1988 DisColonRectum Intraabdominal extrahepatic disease in colorectal metastases 8 Hughes KS, Rosenstein RB, Songhorabodi S, Adson MA, Ilstrup DM,     Fortner JG, Maclean BJ, Foster JH, Daly JM, Fitzherbert D, Sugarbaker PH,     Iwatsuki S, Starzl T, Ramming KP, Longmire Jr. WP, O’Toole K, Petrelli NJ,     Herrera L, Cady B, McDermott W, Nims T, Enker WE, Coppa GF, Blumgart LH,     Bradpiece H, Urist M, Aldrete JS, Schlag P, Hohenberger P, Steele Jr. G,     Hodgson WJ, Hardy TG, Harbora D, McPherson TA, Lim C, Dillon D, Happ R,     Ripepi P, Villella E, Rossi R, Remine SG, Oster M, Connolly DP, Abrams J,     Al-Jurf A, Hobbs KEF, Li MKW, Howard T, Lee E:  Resection of the liver for colorectal     carcinoma metastases. A multi-institutional study of long-term survivors. Diseases     of the Colon     and Rectum 1988;31(1):1-4. 9 Hughes KS, Simon R, Songhorabodi S, Adson MA, Ilstrup DM,     Fortner JG, Maclean BJ, Foster JH, Daly JM, Fitzherbert D, Sugarbaker PH,     Iwatsuki S, Starzl T, Ramming KP, Longmire Jr. WP, O’Toole K, Petrelli NJ,     Herrera L, Cady B, McDermott W, Nims T, Enker WE, Coppa GF, Blumgart LH,     Bradpiece H, Urist M, Aldrete JS, Schlag P, Hohenberger P, Steele Jr. G,     Hodgson WJ, Hardy TG, Harbora D, McPherson TA, Lim C, Dillon D, Happ R,     Ripepi P, Villella E, Rossi R, Remine SG, Oster M, Connolly DP, Abrams J,     Al-Jurf A, Hobbs KEF, Li MKW, Howard T, Lee E:  Resection of the liver for colorectal     carcinoma metastases:  A     multi-institutional study of indications for resection. Surgery     1988;103:278-288. A11 Hughes 1988 Surgery Resection of liver metastases a multiinstitutional study 10 Stephenson KR,     Steinberg SM, Hughes      KS, Vetto JT, Sugarbaker     PH, Chang AE:  Perioperative blood     transfusions are associated with decreased time to recurrence and decreased     survival after resection of colorectal liver metastases.  Annals of Surgery 1988;208(6):679-687. 11 Vetto JT, Hughes KS,     Rosenstein R, Sugarbaker PH:      Morbidity and mortality of hepatic resection for metastatic     colorectal carcinoma.  Diseases of     the Colon     and Rectum  1990;33(5):408-413 12 Morse ED, Gunther     RA, Jesmok GJ, Hughes      KS:  Steroid pretreatment reduces     interleukin-2 toxicity in sheep. Surgery 1990;107(6):639-47. 13 Gagner M, Hughes KS:  Agenesis of gallbladder associated with     neoplasm:  A case report and review     of literature.  Canadian Journal     of Surgery 1991;157:679-681. 14 Camus M, Joshi M,     Mackarem G, Lee A, Rossi R, Munson JL, Buyske J, Barbarisi L, Sanders L, Hughes     KS:  Ductal carcinoma in situ of     the male breast.  Cancer     1994;74(4):1289-1293. 15 Asbun HJ, Tsao JI,     Hughes KS: Resection of hepatic metastases     from colorectal carcinoma. The registry data.  Cancer Treat Res 1994;69:33-41.     Review. 16 Mackarem G, Yacoub     LK, Lee AKS, Barbarisi LJ, Cuttino J, Hughes      KS:  Effects of screening on detection of     lobular carcinoma in situ of the breast:      Non-specificity of mammography and physical examination.  Breast Diseases  1994;7:339-345 17 Detroz B, Sugarbaker     PH, Knol JA, Petrelli N, Hughes      KS:  Causes of death in patients undergoing     liver surgery.  Cancer Treatment     Research 1994;69:241-57. 18 Tsao JI, Asbun HJ,     Hughes KS, Abaubara S, et. Al.:  Hepatoma registry of the western     world.  Repeat hepatic resection     registry. Cancer Treatment Research 1994;69: 21-31. 19 Sugarbaker PH,     Fernandez-Trigo V, Steves M, Shamsa F, Hughes KS:  Repeat liver resections from colorectal     metastasis. Surgery. 1995;117:296-304. 20 Joshi MG, Lee AKC,     Loda M, Camus MG, Pedersen C, Heatley GJ, Hughes KS:  Male breast carcinoma: an evaluation of     prognostic factors contributing to a poorer outcome.  Cancer 1996;77(3):490-8. 21 Joshi MG, Lee AKC,     Pedersen CA, Schnitt S, Camus MG, Hughes KS: The role of     immunocytochemical markers in the differential diagnosis of proliferative     and neoplastic lesions of the breast. Modern Pathology 1996;9(1):57-62. 22 Hughes KS, Lee AKC, McLellan R, Mackarem G, Camus M, Joshi M,     Walsh JM, Heatley GJ, Rossi RL, Munson JL, Braasch JW, Tsao J, Sanders LE,     Barbarisi LJ, Lo TCM, Girshovich L, Healey GA, Buyske J:  Breast-conserving therapy for patients     with ductal carcinoma in situ.  Breast     Diseases 1996;9:255-268.  23 Lee KC, Loda M,     Bosari S, Mackarem G, DeLellis RA, Heatley GJ, Hughes KS:  Node-negative invasive breast carcinoma     1cm or less in size (T1a,bNoMo) –Clinicopathologic features and     outcome.  Cancer 1996;79 (4):     761-771. 24 Hughes KS, Pinsky CM, Petrelli NJ, Moffat, FL, Patt YZ,     Hammershaimb L, Goldenberg, DM:  Use     of carcinoembryonic antigen radioimmunodetection and computed tomography     for predicting the arcinomality of recurrent colorectal cancer.  Annals of Surgery.  1997;226(5): 621-631. 25 Pandya S, Mackarem     G, Lee AKC, McLellan R, Heatley GJ, Hughes KS:  Ductal carcinoma-in-situ:  the impact of screening on clinical     presentation and pathologic features.      The Breast Journal  1998;4(3): 146-151 26 Marsh DJ, Caron S,     Dahia PLM, Kum JB, Frayling IM, Tomlinson IPM, Hughes KS,Eeles     RA, Hodgson SV, Murday VA, Houlston R, Eng C.:  Germline PTEN Mutations in cowden     syndrome-like families.  J Med     Genet 1998;35(11):881-5. 27 Rieger-Christ KM,     Pezza JA, Dugan JM, Braasch JW, Hughes KS, Summerhayes IC:  Disparate E-cadherin mutations in LCIS     and associated invasive breast carcinomas.      Molecular Pathology 2001;54(2):91-7. 28 Mackarem G, RocheCA, Hughes KS:  The effectiveness of the Gail model in     estimating risk for development of breast cancer in women under 40 years of     age. Breast Journal 2001;7(1):34-39. 29 Euhus DM, Smith     KC, Robinson L, Stuky A, Olopade OI, Cummings S, Garber JE, Chittenden A,     Mills GB, Rieger P, Esserman L, Crawford B, Hughes KS, Roche CA, Ganz     PA, Joyce Seldon, Fabian CJ, Klemp J, Tomlinson G: Pre-test prediction of     BRCA1 or BRCA2 mutation by risk counselors and the computer model     BRCAPRO.  JNCI 2002;94(11):844-851 A35 Euhus 2002 JNatlcancerInst Pretest prediction of BRCA1 30 Berry DA, Iversen ES, Gudbjartsson DF, Hiller EH, Garber JE, Peshkin     BN,  Lerman C,Watson P,     Lynch HT,Hilsenbeck SG, Rubinstein WS, Hughes KS,     Parmigiani G:  BRCAPRO Validation,     sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other     breast cancer susceptibility genes. JCO     2002;20(11):2701-2712. A36 Berry 2002 JClinOncol BRCAPRO validation 31 Parisky YR, Sardi     A, Hamm R, Hughes      KS, Esserman L, Rust S,     Callahan K: Efficacy of computerized infrared imaging analysis in the     discrimination of mammographically suspicious lesions.  American J of Roentgenology 2002;180:     263–269. 32 Michaelson JS,     Silverstein M, Wyatt J, Weber G, Moore R, Kopans DB, Hughes KS:     Predicting the survival of patients with breast carcinoma using tumor size.     Cancer 2002;95:713-23. 33 Hughes KS, Roche      CA, Campbell CT, Siegel N, Salisbury L,     Chekos A, Katz MS, Edell E: Prevalence of family history of breast and     ovarian cancer in a single primary care practice using a self-administered     questionnaire. The Breast Journal 2003 Jan-Feb;9(1): 19-25. 34 Michaelson J, Satija S, Moore R, Weber G, Halpern E,Garland A, Kopans     D, Hughes KS: Estimates of the sizes at which breast cancers become     detectable on mammographic and on clinical grounds.  J Women’s Imaging 2003;5:10-19 35 Kopans DB,     Rafferty E, Georgian-Smith D, Yeh E, D’Alessandro H, Moore R, Hughes KS,     Halpern E:  A simple model of breast     cancer growth may provide explanations for observations of apparently     complex phenomena.  Cancer     2003;97(12): 2951-2959 36 del Carmen MG , Hughes     KS, Halpern E, Rafferty E, Kopans D, Parisky YR, Sardi A, Esserman L,     Rust S, and Michaelson J:  Racial     differences in mammographic breast density. Cancer 2003 Aug 1;98(3): 590-6 A42 Del Carmen 2003 Cancer Race and mammo density 37 Michaelson JS,     Satija S, Kopans DB, Moore RA, Silverstein, M, Comegno A, Hughes KS,     Taghian A, Powell S, Smith, B:      Gauging the impact of breast cancer screening, in terms of tumor     size and death rate.  Cancer     2003:98(10):2114-2124 38 Michaelson JS     Silverstein M, Sgroi D Cheongsiatmoy JA, Taghian A Powell Hughes KS,     Cogmegno A, Tanabe K, Smith BA:  The     effect of tumor size and nodal status on the lethality of breast     cancer.  Cancer 2003;98(10):2133-2143 39 Blanchard K, Colbert JA, Puri D, Weissman J, Moy B, Kopans DB,     Kaine EM, Moore RH, Halpern EF, Hughes      KS, Tanabe KK, Smith BL,     Michaelson JS: Mammographic     screening: patterns of use and estimated impact on breast carcinoma     survival. Cancer 2004 Aug 1;101(3):495-507. A45 Blanchard 2004 Cancer Mammographic screening use and impact 40 Hughes KS,     Schnaper LA, Berry D, Cirrincione C, McCormick B, Smith T, Shank B, Smith BL,     Shapiro C, Muss HB, Winer E, Hudis C, Wood W, Sugarbaker D, Henderson IC, Norton     L; CLG Group B; RTOG; ECOG: Lumpectomy plus Tamoxifen with or without     irradiation in women 70 years of age or older with early breast     cancer.  New      England Journal of Medicine 2004 Sep 2;351(10):     971-7. 41 Colbert, J Bigby JA, Smith D, Moore R, Rafferty E, Georgian-Smith D,     D’Alessandro HA, Yeh E, Kopans DB, Halpern E, Hughes KS,     Smith BL, Tanabe KK, Michaelson J:      The age at which women begin mammographic screening. Cancer 2004;101:     1850-1859. 42 Jones JL, Hughes KS,     Howard-McNatt M, Kopans DB, Moore RH, Hughes SS, Lee NY, Roche CA, Siegel N, Gadd MA, Smith BL,     Michaelson JS:  Evaluation of     hereditary risk in a mammography population.  Clinical Breast Cancer 2005 Apr;6(1):     38-44.A49Jones2005ClinBrCaIncidenceHeredRiskMammoPop 43 Blanchard K, Colbert J, Kopans D, Moore R, Halpern E, Hughes KS,     Tanabe K, Smith BL, Michaelson JS:      Long term risk of false positive screening results and subsequent     biopsy, as a function of mammography use.      Radiology 2005;240: 335-342. 44 Shabo A, Hughes      KS:  Family history     information exchange services using HL7 clinical genomics standard     specifications.  Int’l Journal on Semantic Web and Information     Systems.2005;1(4): 42-65 45 Jones JL, Zabicki K, Christian RL, Gadd MA, Hughes KS,     Lesnikoski BA, Rhei E, Specht MC, Dominguez FJ, Smith BL: A comparison of     sentinel node biopsy before and after neoadjuvant chemotherapy: timing is     important. American Journal of Surgery 2005 Oct; 190(4): 517-20. 46 Dominguez FJ, Jones JL, Zabicki K, Smith BL, Gadd MA, Specht MC,     Kopans DB, Moore RH, Michaelson JS, Hughes      KS:  Prevalence of hereditary breast/ovarian     cancer risk in patients with a personal history of breast or ovarian cancer     in a mammography population.  Cancer    2005 Nov 1;104(9): 1849-53. 47 Schwartz GF, Veronesi U, Clough KB, Dixon JM, Fentiman IS,     Heywang-Kobrunner SH, Holland R, Hughes KS, Mansel RE, Margolese R,     Mendelson EB, Olivotto IA, Palazzo JP, Solin LJ: Consensus Conference     Committee.  Proceedings of the     consensus conference on breast conservation, Milan, Italy, April 28-May 1,     2005: Simultaneously published in:  Int     Journal Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1281-8. J Am Coll     Surg. 2006 Aug;203(2):198-207.  Breast     J. 2006 Jul-Aug;12(4):398-407.  Cancer.     2006 Jul 15;107(2):242-50. 48 Zabicki K, Colbert JA, Gadd MA, Hughes KS, Jones JL, Specht     MC, Dominguez FJ, Smith BL:  Breast     cancer diagnosis in women <40 vs. 50-60: increasing size and stage     disparity compared with older women over time.  Ann Surgical Oncology 2006     Aug;13(8):1072-7.  Epub 2006 Jul 19. 49 K.R. Kozak, B. L. Smith, J.  Adams, E. Kornmehl, A.  Katz, M. Gadd, M. Specht, K. Hughes,     V Gioioso, H-M Lu, K. Braaten, A. Recht, S. N. Powell, T. F. DeLaney     and A. G. Taghian. Accelerated Partial     Breast Irradiation Using Proton Beams: Initial Clinical Experience Int J     Radiat Oncol Biol Phys,2006 Nov 1;66 (3):691-86. 50 Dominguez FJ, Black DM, KawaguchiAL, O’Malley CA, Hughes KS.  Elastic stay     hooks and self-retaining retractor technique for mastectomy skin     flaps.  Surgery     2007 Feb;141(2):272-4. Epub 2006     Aug 30. No abstract available. 51 Dominguez FJ, Lawrence C, Halpern EF, Drohan B, Grinstein G, Black     DM, Smith BL, Gadd MA, Specht MC, Kopans DB, Moore RH, Hughes     KS, Roche     CA, Hughes      KS:  Accuracy of self-reported personal     history of cancer in an outpatient breast center.  Journal of Genetic Counseling 2007     June;16(3):341-5.  Epub2007 May 17. 52 Del Carmen MG, Halpern EF, Kopans DB, Moy B, Moore RH, Goss P, Hughes     KS: Mammographic breast density and race.  American Journal of Roentgenology     2007;188(4):1147-50. 53 Black D, Specht M, Lee JM, Dominguez F, Gadd M, Hughes KS,     Rafferty E, Smith B:  Detecting     occult malignancy in prophylactic mastectomy: preoperative MRI versus     sentinel lymph node biopsy.  Annual     Surgical Oncology 2007;14(9):2477-84.      Epub 2007 Jun 22. 54 Dominguez F,     Golshan M, Black D, Hughes KS, Gadd M, Christian R, Lesnikoski B,     Specht M, Michaelson J, Smith B.      Sentinel Node Biopsy is Important in Mastectomy for Ductal Carcinoma     in Situ.  Annals of     Surgical Oncology; 2008 Jan;15(1):268-73.  Epub     2007 Sep 22. 55 Hughes KS.  Why do we believe that breast     cancer in the elderly is the same as breast cancer in young women?  Drugs Aging. 2008;25(1):47-8. 56 Murphy CD, Jones     JL, Javid SH, Michaelson JS, Nolan ME, Lipsitz SR, Specht MC, Lesnikoski     BA, Hughes KS, Gadd MA, Smith     BL.  Do sentinel node micrometastases     predict recurrence risk in ductal carcinoma in situ and ductal carcinoma in     situ with microinvasion?  American Journal of Surgery. 2008     Oct;196(4):566-8. Epub 2008 Aug     29. 57 Murphy CD, Lee JM,     Drohan B, Euhus DM, Kopans DB, Rafferty EA, Specht MA, Smith BL, Hughes     KS.  The American Cancer Society     Guidelines for Breast Screening with Magnetic Resonance Imaging: An     Argument for Genetic Testing.  Cancer,     2008 Dec 1;113(11):3116-20. 58 Schwartz GF, Hughes KS,     Lynch HT, Fabian CJ, Fentiman IS, Robson ME, Domchek SM, Hartmann LC,Holland R,Winchester     DJ, and the Consensus Conference Committee.      Proceedings of the International Consensus Conference on Breast     Cancer Risk, Genetics, & Risk Management, April, 2007. Breast J. 2009     Jan-Feb; 15(1): 4-16. 59 Ozanne EM, Loberg A, Hughes S, Lawrence C,     Drohan B, Semine A, Jellinek M, Cronin C, Milham F, Dowd D, Block C,     Lockhart D, Sharko J, Grinstein G, Hughes     KS.  Identification and management of     women at high risk for hereditary breast/ovarian cancer syndrome.  Breast     Journal. 2009 Mar-Apr;15(2):155-62. 60 Javid SH, Kirstein     LJ, Rafferty E, Lipsitz S, Moore R, Rusby JE, Murphy CD, Hughes KS, Specht     MC, Taghian AG, Smith BL.  Outcome of     Multiple Wire Localization for Larger Breast Cancers: Do Multiple Wires     Translate Into Additional Imaging, Biopsies, and Recurrences? American Journal of Surgery, 2009 Sep;198(3):368-72. 61 Alm El-Din MA, Hughes KS, Raad RA, Goldberg SI, Aisenberg AC, Niemierko A,     Taghian AG.  Clinical outcome of breast cancer     occurring after treatment for Hodgkin’s lymphoma: case-control analysis.  Radiation     Oncology 2009 Jun 30;4:19. 62 M. Alm El-Din M, Hughes     KS, Finkelstein D, Betts K, Yock T, Tarbell N, Aisenberg A and Taghian     AG. Breast cancer after treatment of Hodgkin’s lymphoma: Risk factors that     really matter. Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):69-74.     Epub 2008 Jun 4. 63 Samphao S, Wheeler     AJ, Rafferty E, Michaelson JS, Specht MC, Gadd MA, Hughes KS,     Smith BL. Diagnosis of breast cancer in women age 40 and younger: delays in     diagnosis result from underuse of genetic testing and breast imaging.  Am     J Surg. 2009Oct;198(4):538-43. 64 Coopey SB, Buckley     JM, Smith BL, Hughes KS, Gadd MA, Specht MC.     Lumpectomy Cavity Shaved Margins Do Not Impact Re-excision Rates in Breast     Cancer Patients. Annals of Surgical     Oncology. 2011 Oct;18(11):3036-40. Epub 2011 Sep 27. 65 Coopey S, Smith     BL, Hanson S, Buckley J, Hughes KS,     Gadd M, Specht MC.  The Safety of Multiple Re-Excisions after     Lumpectomy for Breast Cancer.  Annals of Surgical Oncology. 2011     Dec;18(13):3797-801. Epub 2011 Jun 1. 66 Metcalfe     KA, Mian N, Enmore     M, Poll A, Llacuachaqui     M, Nanda S, Sun P, Hughes KS, Narod     SA. Long-Term     Follow-Up of Jewish Women with a BRCA1 and BRCA2 Mutation Who Underwent     Population Genetic Screening. Breast     Cancer Research and Treatment. 2012 Jun;133(2):735-40. Epub 2012     Jan 13.

 

 

 

 

 

 

 

 

 

 

 

 

 

Reviews, Chapters, and Editorials

1 Sugarbaker PH, Hughes KS,     Barofsky I, Copeland E:  Quality of     life and cost effectiveness issues in the management of patients with     hepatic metastases from colorectal cancer.      In:  Mastromarino AJ, ed.  The Biology and Treatment of     Colorectal Cancer Metastasis.Boston:  Martinus Nijhoff.  1986. p83-98 2 Hughes KS, Sugarbaker PH:      Resection of the liver for metastatic solid tumors.  In:      Rosenberg SA, ed.  Surgical     Treatment of Metastatic Cancer. Philadelphia:  Lippincott.  1987. p125-164  3 Sugarbaker PH, Reinig J, Hughes KS:  Diagnosis of metastatic disease to the     liver.  In:  Rosenberg SA, ed.  Surgical Treatment of Metastatic Cancer.  Philadelphia:  Lippincott. 1987.  p101-123 4 Hughes KS, Scheele J, Sugarbaker PH:  Surgery for metastatic colorectal cancer     to the liver:  Optimizing the results     of treatment.  Surgical Clinics of     North America1989;69:339-359.  5 Hughes KS:  The surgical     treatment of metastatic colorectal cancer.      Seminars in Colorectal Surgery 1990;1:57-62. 6 Levitan N, Hughes KS:     The management of non-resectable liver metastases from colorectal cancer. Oncology     1990;4(11):77-84; discussion 84, 89, 92. 7 Schirmer WJ, Hughes KS,     Rossi RL, Munson JL, Braasch JW:      Common operative problems in hepatobiliary surgery.  Surgical Clinics of North      America 1991;71(6):1363-1389. 8 Hughes KS, Rossi RL:      Colorectal cancer metastatic to the liver:  resection.  In:      Cameron, ed.  Current     Surgical Therapy.  St. Louis: Mosby-Year     Book. 1992. p284-288 9 Hughes KS:  Liver, biopsy     and segmental resection.  In:  Daly JM, Cady B, eds.  Atlas of Surgical Oncology.  St.       Louis:      Mosby-Year Book. 1992. p327-343 10 Sugarbaker PH, Hughes KS:  Surgery for colorectal metastases in the     liver.  In:  Wanebo H, ed.  Colorectal Cancer. St.       Louis:      Mosby-Year Book. 1993. p405-413 11 Hughes KS, Sugarbaker PH:      Hepatic resection using ultrasonic fragmentation.  In:      Braverman M, ed.  Surgical     Technology International.      Century Press:  London. 1992 12 Mackarem G, Barbarisi L, Hughes KS:  The role of axillary dissection in early     stage breast cancer.  Cancer     Investigations 1992;10(5):461-470. 13 Hughes KS:  Technique for     axillary dissection:  Use of the     Bookwalter retractor.  Contemporary     Surgery 1993; 42(3):189-193 14 Asbun HJ, Hughes KS:  Management of recurrent and metastatic     colorectal carcinoma.  Surgical     Clinics of North America 1993;73(1):145-166. 15 Asbun HJ, Tsao J, Hughes KS:  Resection of hepatic metastases from     colorectal carcinoma:  The registry     data.  Cancer Treatment Research     1994. 69: 33-41. 16 Tsao J, Asbun HJ, Hughes KS     , Abaubara S, August DA, Azurin A, Braasch JW, Broelsh C, Cady B, Chang AE,     et al.   Hepatoma registry of the Western     world. Repeat Hepatic Resection Registry. Cancer Treatment Research     1994; 69:21-31. 17 Tsao JI, Molgaard CP, White     CF, Hughes KS:  Hepatic Metastases In:  Pitt HA, Carr-Locke DL, Ferrucci JT,     eds.  Little Brown and Company, 1995. 18 Hughes KS, Lee AK, Rolfs A:      Controversies in the treatment of ductal carcinoma in situ.  Surgical Clinics of North      America 1996;76(2):243–265. 19 Hughes KS, Roche      CA:  How do we apply genetic testing for     breast cancer susceptibility to clinical practice?  Journal of Surgical Oncology 1996;62(3):155-157.     No abstract available. 20 Buyske J, Mackarem G, Ulmer     BC, Hughes KS:      Breast Cancer in the Nineties.      Association of periOperative Registered Nurses Journal     1996;64 (1): 64-72. 21 Inouye P, Schnaper, LA, Buyske     J, Shank BM, Shapiro CL, Berry DA, Wilder KLM, Hughes KS:  Carcinoma of the breast in the geriatric     population.  Surgical Rounds     1997;4 (3): 146-20. 22 Hughes KS, Papa MZ, Whitney T, McLellan R:  Prophylactic mastectomy and inherited predisposition     to breast carcinoma. Cancer 1999;86(11 Suppl): 2502-16. Review. 23 Hughes KS, Papa MZ, Whitney T, McLellan R:  Prophylactic Surgery and Inherited Cancer     Predisposition.  In:  Shaw G, Ed.    Cancer Genetics for the Clinician, Plenum     Publishers. 1999. p103-134. 24 RocheCA, Lucas MR, Hughes KS:     Development of a Risk Assessment Clinic.      In:  Vogel V (ed.) Management     of Women at High Risk for Breast Cancer. Blackwell Science, Inc. 1999.     p.166-182. 25 Levine A, Hughes KS:     Cost-Effectiveness of the Identification of Women at High Risk for the     Development of Breast and Ovarian Cancer.      In: Vogel V (ed.) Management of Women at High Risk for Breast     Cancer. Blackwell Science, Inc.      1999 p. 262-276. 26 Hughes KS, Roche      CA, Whitney T, McLellan     R.  The Management of women at high     risk of experiencing hereditary breast and ovarian cancer: The Lahey     Guidelines.  Dis Manage Health     Outcomes, 2000;7(4): 201-215. 27 Shuster TD, Girshovich L,     Whitney TM, Hughes      KS:     Multidisciplinary care for patients with breast cancer.  Surgical Clin NA, 2000;80(2):     505-33. Review. 28 Argy O, Hughes     KS, Roche     CA: Management of the Patient With a     Breast Mass.  In: Manual of Breast Diseases,     Lippincott. 2001 29 Schnaper LA, Hughes KS:     Special considerations when treating breast cancer in the elderly.  Breast Disease – An International     Journal 2001;12: 83-93. 30 Hughes KS, Roche CA. Hormone therapy revisited: data from the     population, treatment for the patient. Menopause 2003;10(4):269-70. 31 Schnaper     LA, M.D.Hughes      KS, M.D., for the     Cancer and Leukemia Group B, Radiation Therapy, Oncology Group, and Eastern     Cooperative Oncology Group: Can radiation be omitted following breast     conserving surgery in women over 70 with early stage breast cancer? The     American Journal of Oncology Review. In Press.  2004 32 Howard-McNatt M, Hughes KS,     Schnaper LA, Jones JL, Gadd MA, Smith BL: Breast cancer treatment in older     women. Surgical Clin NA, 2005 Jan;14(1): 85-102, vi. Review. 33 Schwartz GF, Veronesi U,     Clough KB, Dixon JM, Fentiman IS, Heywang-Kobrunner SH, Holland R, Hughes     KS, Mansel RE, Margolese R, Mendelson EB Olivotto IA, Palazzo JP, Solin     LJ; Consensus Conference Committee: Proceedings of the consensus conference     on breast conservation.  Simultaneous     Publications:  International Journal     of Radiation Oncology Biol Phys. 1;65(5):1281-8.  J American College     of Surgery. 203(2):198-207. Breast J. 12(4):398-407.  Cancer 2006:107(2):242-50. 34 Kirstein LJ, Taghian A, Hughes KS.  Management     and Outcomes of Ipsilateral Recurrence Following Breast Conservation.      Seminars in Breast Disease 2007 (Vol 10:4) p. 169-177. 35 Schnaper LA, Hughes KS:  The use of radiation in the elderly. Breast     Cancer Online 2007;10(1): 1-3. 36 Hughes KS. Why do we believe that breast cancer in the elderly     is the same as breast cancer in young women?  Drugs and Aging 2008;25(1):47-8.     No abstract available. 37 Carlson RW, Moench S, Hurria     A, Balducci L, Burstein HJ, Goldstein LJ,Gradishar WJ, Hughes KS, Jahanzeb M, Lichtman SM,     Marks LB, McClure JS, McCormick B, Nabell LM, Pierce LJ, Smith ML, Topham     NS, Traina TA, Ward JH, Winer EP.      NCCN Task Force Report: breast cancer in the older woman.  The Journal of the National Comprehensive     Cancer Network. 2008;6 Suppl     4:S1-S25.  QuizS26-S27. Review. 38 Murphy C, Jones J, Javid S,     Michaelson M, Noaln M, Lipsitz S, Specht M, Lesnikoski B, Hughes KS,     Gadd M, Smith S: Do Sentinel Node Micrometastases Predict Local Recurrence     Risk in Ductal Carcinoma in Situ (DCIS) and Ductal Carcinoma in Situ with     Microinvasion (DCISM)?  American     Journal of Surgery.  2008 (Epub     ahead of print) 39 Kirstein L, Raffert E, Specht     M, Moore R, Taghian A, Hughes      KS, Gadd M, Smith B.  Outcomes of multiple wire localization     for larger breast cancers: when can mastectomy be avoided?  J Am Coll Surg. 2008;     207(3):342-6. Epub 2008 Jun 2. 40 Dominguez F, Golshan M, Black     D, Hughes KS, Gadd M, Christian R, Lesnikoski B, Specht M,     Michaelson J, Smith B.  Sentinel node     biopsy is important in mastectomy for ductal carcinoma in situ.  Ann Surg Oncol. 2008     Jan;15(1):268-73. Epub 2007 Sep 22. 41 Murphy CD, Lee JM, Drohan B,     Euhus DM, Kopans DB, Gadd MA, Rafferty EA, Specht MC, Smith BL, Hughes     KS. The American Cancer Society guidelines for breast screening with     magnetic resonance imaging: an argument for genetic testing. Cancer. 2008 Dec 1; 113(11):     3116-20. 42 Kimmick G, Hughes KS,     Muss H: Breast Cancer in Older Women.      In: Harris J, Lippman M, Morrow M, Osborne C (eds.)     Diseases of the Breast, Lippincott Williams and Wilkins. 2004 and 2009 43 Drohan B, Ozanne EM, Hughes KS.     Electronic health records and the management of women at high risk of     hereditary breast and ovarian cancer. Breast     Journal 2009 Sep-Oct;15 Suppl     1:S46-55. 44 Pandalai PK, Mariciani V, Lerwill MF, Roche    CA, Hughes      KS.   The Medical and Surgical Management of     Atypical Hyperplasia and LCIS.      In:  Multidisciplinary     Approach to Breast Cancer.  Eds:     Taghian A, Smith BL, Erban J.  Demos     Medical Publishing,New York.     2009. 45 Schwartz GF, Hughes KS,     Lynch HT, Fabian CJ, et. al. Proceedings of the international consensus     conference on breast cancer risk, genetics, & risk management, April,     2007. The Breast Journal 2009     Jan; 15(1). 46 Ozanne EM, Loberg A, Hughes S,     Lawrence C, Drohan B, Semine A, Jellinek M, Cronin C, Milham F, Dowd D,     Block C, Lockhart D, Sharko J, Grinstein G, Hughes KS. Identification     and management of women at high risk for hereditary breast/ovarian cancer     syndrome. The Breast Journal 2009     Mar-Apr; 15(2): 155-62. 47 Hughes, KS,     Ravnikar, V.  Risk Assessment and     Management of Women with BRCA Mutations.      In: A Supplement to The Female Patient. 2009, Nov. 48 Hughes, KS.     Smith, BL, Wheeler, A. The Cancer and Leukemia Group B Trials. In: Breast     Surgical Oncology.New York,     New York: McGraw Hill; 2010.     [in press] 49 Hughes, KS,     Hughes, S, Mahmoud, ET. The Potential of the Electronic Health Record in     theBreastCenter. In: Breast Surgery.New York,New       York: Springer Science + Business Media; 2010. 50 Kawamoto K, Del Fiol G,     Strasberg HR, Hulse N, Curtis C, Cimino JJ, Rocha BH, Maviglia S, Fry E,     Scherpbier HJ, Huser V, Redington PK, Vawdrey DK, Dufour JC, Price M, Weber     JH, White T, Hughes KS,McClay     JC, Wood C, Eckert K, Bolte S, Shields D, Tattam PR, Scott P, Liu Z,     McIntyre AK.  Multi-National,     Multi-Institutional Analysis of Clinical Decision Support Data Needs to     Inform Development of the HL7 Virtual Medical Record Standard.  AMIA Annu Symp Proc. 2010 Nov     13;2010:377-81. 51 Hughes KS,Roche     CA: The complexity of breast     cancer risk needs to be embraced, not oversimplified. Menopause. 2011 Jun;     18(6): 599-600. No abstract available. 52 Hughes KS, El-Tamer, Mahmoud, Hughes, Sherwood,Drohan, Brian, Sharko, John,Lawrence,     Christine, Loberg, Andrea, Grinstein, George Chapter 79 The Potential of     the Electronic Health Record in theBreastCenter.  In:      Breast Surgery: Office Management and Surgical Technique.  Eds: Scott-Conner CEH, Dirbas FM.  Springer. 2011. 53 Buckley     JM, Hughes KS. Aromatase inhibition to decrease     background parenchymal enhancement: premedication before magnetic resonance     imaging? Menopause. 2012 Apr;19(4):385-6. PMID:22453132 54 Drohan B, Roche    CA, Cusack JC Jr., Hughes KS:Hereditary Breast and     Ovarian Cancer and Other Hereditary Syndromes: Using Technology to Identify Carriers. Annals of Surgical Oncology. 2012     Jun;19(6):1732-7. Epub 2012 Mar 17. 55 Cusack JC Jr., Hughes KS.     Managing Patients at High Risk for Hereditary Breast Cancer: A Guide for     the Practicing Physician. Annals of     Surgical Oncology. 2012 Jun;19(6):1721-2. 56 Ozanne EM, O’Connell A, Bouzan C, Bosinoff P, Rourke T,     Dowd D, Drohan B, Millham F, Griffin P, Halpern EF, Semine A, Hughes KS. Bias in the Reporting of     Family History: Implications for Clinical Care. J Genet Couns. 2012 Aug;21(4):547-56.     Epub 2012 Jan 12. 57 Buckley JM, Coopey SB, Sharko J, Polubriaginof F, Drohan     B, Belli AK, et al. The feasibility of using natural language processing to     extract clinical information from breast pathology reports. J Pathol Inform     2012;3:23.

 

 

Books, Monographs, and Text Books

1.	Hughes KS,   August DA, Ottow RT, Sugarbaker PH:    Hepatic resection for colorectal carcinoma metastases:  Present status and future prospects.  In:    Mastromarino AJ, ed.  The Biology and Treatment of Colorectal   Cancer Metastasis. Boston: Martinus   Nijhoff.  1986. p159-178

 

 

Clinical Communications

1.	Hughes KS,   Villella E:  An improved technique for   regional perfusion chemotherapy in the presence of a replaced right hepatic   artery using a single implantable pump.    Surgery 1984;95(3):355-357.
2.	Hughes KS,   Happ RA:  A simple device to facilitate   the “double stapling technique” for low anterior resection. Diseases of the Colon and Rectum 1984;27(10):684-685.
3.	Hughes KS,   Sugarbaker PH:  Extrahepatic tumor   deposits misdiagnosed as intrahepatic metastases.  Archives   of Surgery 1988;123(8):1013-1015.
4.	Buyske J, Hughes KS,   Tronic BS:  Adenoma of the nipple.  Surgical   Rounds 1995;18(8): 323-24.
5.	Hughes KS,   Barbarisi L, Rossi RL, Walsh J., deCrescinzo N:  Using continuous quality improvement (CQI)   to improve the care of patients with breast cancer. Adm Radiol J. 1997:16(6-7): 19-20, 26-7. No abstract available.
6.	Mackarem G, RocheCA, Silverman ML, Hughes KS:  The development of new, primary,   noninvasive carcinoma of the breast 29 years after bilateral radical   mastectomy.  The Breast Journal   1998;4(1): 51-54
7.	Katz M, Schapira L, Harisinghani M, Hughes KS:   Palpable right breast mass in a pregnant woman. Nature Clinical Practice Oncology 2005 Apr;2(4):218-221; quiz 1 p   following 222.
8.	Shi AA, Georgian-Smith   D, Cornell LD, Rafferty EA, Staffa M, Hughes KS,   Kopans DB: Radiological reasoning: male breast mass with calcifications.  American   Journal of Research 2005;185: S205-213.
9.	Dominguez FJ, KawaguchiAL, O’Malley C, Hughes KS:  Elastic stay hooks and bookwalter retractor   technique for raising mastectomy skin flaps.    Surgery 2007;141(2):272-4.

 

Abstracts and Original Scientific Research Presentations

1.	Laurie Kirstein, M.D., Elizabeth Rafferty, M.D., Richard   Moore, Ph.D.,  Jennifer Rusby, M.D.,   Michelle C. Specht, M.D., Kevin S.   Hughes, M.D. and Barbara L. Smith, M.D., Ph.D., Outcome of Multiple   Wire Localization for Larger Breast Cancers: When Can Mastectomy be Avoided?   Society of Surgical Oncology, 2007, Poster Presentation. 2007
2.	Kirstein L, Hitt R, Gadd M, Hughes KS,   Rafferty E, Moore R, Kopans Specht M, How Are Metachronous Breast Cancers   Detected – Screening Mammography or Clinical Breast Exam? American   Society of Breast Surgeons, 2007, Poster Presentation 2007
3.	Kirstein LJ, Marte Y, Michaelson J, Roche C, Smith BL,   Specht MC, Gadd MA, Drohan B, Lawrence C and Hughes KS:   LCIS and Tamoxifen Use: A single Institution Review. ASCO, Poster   Presentation. June 2007
4.	Murphy C, Jones J, Javid S, Michaelson M, Noaln M,   Lipsitz S, Specht M, Lesnikoski B, Hughes   KS, Gadd M, Smith B. Do Sentinel   Node Micrometastases Predict Local Recurrence Risk in Ductal Carcinoma in   Situ (DCIS) and Ductal Carcinoma in Situ with Microinvasion (DCISM)?   Poster.  American Society of Breast   Surgeons 9th Annual Meeting, 2008.
5.	Hughes K,   Ozanne E, Semine A, Drohan B. Decision   Support System for the Identification and Management of Women at High Risk   for Hereditary Breast/Ovarian Cancer Syndrome. Annual Society of Medical   Decision Making Conference, 2008 (submitted).
6.	Ozanne EM, Sharko J, Drohan B, Grinstein G, Hughes KS.   Identification of high-risk lesions   through automated natural language processing (NLP) of pathology reports.   San Antonio Breast Cancer Symposium. 2008.
7.	Wheeler A, Samphao S, Drohan B, Specht M, Gadd M,   Moore R, Kopans D, Smith B, and Hughes   KS.  Trends Among BMI (BMI) and Tumor Size in Breast Cancer: Size Does Not   Matter. American Society of Breast Surgeons,   Poster Presentation, 2009.
8.	Wheeler AJ,   Zhang A, Drohan B, Lawrence C,   Roche C, Kopans DB, Moore RH, Smith BL, Sharko J, Hughes KS.   Predicting risk of developing   invasive breast cancer   in the African American female population, ASCO,   2009
9.	Samphao S, Wheeler A, Rafferty E, Michaelson J, Specht M,   Gadd M, Hughes KS, Smith B.  Diagnosis   of Breast Cancer in Women Age 40 and Younger: Delays in Diagnosis Are Common   Due to Underutilization of Genetic Testing and Breast Imaging. American   Society of Breast Surgeons, Poster Presentation, 2009
10.	Lumpectomy plus tamoxifen with or without irradiation in   women 70 years of age or older with early breast cancer.  Hughes   KS, Schnaper LA, Cirrincione C, Berry DA, McCormick B, Muss HB, Shank B,   Hudis C, Winer EP, Smith BL, CALGB, ECOG, RTOG.  ASCO, 2010.
11.	Kim EMH, Sharko J, Drohan B, Roche C, Specht M, Gadd M,   Smith BL, Hughes KS. The Utility   of Natural Language Processing and Incidence of High Risk Breast Disease.   Poster presentation MGH SAC, 2010.
12.	Fiedler AG,   Dominguez F, Kim EMH, Specht M, Hughes   KS, Gadd MA. Taghian A, Golshan M, Michaelson J, Smith BL. Risk of   axillary recurrence after a negative sentinel node biopsy (SNB) without   radiation: implications for partial breast irradiation. Submitted to American   Society of Clinical Oncology Breast Symposium Oct 1-3, 2010.
13.	Kim EMH, Sharko J, Drohan B, Roche C, Zhou YB, Specht M,   Gadd MA, Smith BS, Hughes KS. The   Utility of Natural Language Processing (NLP) in determining the Incidence of   High Risk Breast Disease and the Subsequent Development of Breast Cancer.   Poster presentation Society of Surgical Oncology 63rd Annual Cancer   Symposium, March, 2010.
14.	Lin B, McInerney J, Edelman E, Hughes KS, Drohan B, Sharko J, Wolfberg A, O’Leary J, Edelson V,   Kyler P, Puryear M, Dolan S.    Integrating Family Health History into the Primary Prenatal   Clinic.  Presented at the Annual   Clinical Genetics Meeting of theAmerican   College of Medical   Genetics, March, 2010.
15.	Kim EMH, Sharko J, Drohan B, Roche C, Smith BL, Hughes KS. To Screen or Not to Screen   – American Cancer Society Guideline for MRI Screening in Patients who are   Diagnosed with LCIS. Poster presentation Am Society of Breast Surgeons Annual   Conference, April, 2010.
16.	Hughes, KS.  A Patient Entered Family Health History   Tool to Initiate Guidelines for Prenatal Genetic Testing Using Clinical   Decision Support. Presented as the Bio-IT World Conference & Expo.  2010
17.	Kim EMH, Sharko J, Drohan B, Roche C, Smith BL, Hughes KS. To Screen or Not to Screen   – American Cancer Society Guideline for MRI Screening in Patients who are   Diagnosed with LCIS. Poster presentation, MGH, Clinical Research Day   Competition, May, 2010.
18.	Kim EMH, Sharko J, Roche C, Drohan B, Specht M, Gadd M,   Smith BL, Hughes KS. Risk Disease   and Diagnosis on Core Biopsies Stratified by Ethnicity. Poster presentation   Am Society of Clinical Oncology. Annual Meeting, June, 2010.
19.	Kyler P, Dolan S, O’Leary J, Edelman E, Hughes KS.  Family history, prenatal care, and novel   health information technology:  a   collaborative risk assessment and educational tool for health professionals   and the public.  Workshop at the   GeneticAlliance   Annual Meeting, July 17, 2010.
20.	Kim EMH, Sharko J, Drohan B, Roche C, Zhou YB, Specht M,   Gadd MA, Smith BS, Hughes KS.   Extracting Useful Information from Pathology Reports.
21.	Kim, EMH, Sharko, JR, Drohan, B, Roche, CA, Specht, MC,   Gadd, MA, Smith, BL,  Hughes, KS. The Utility of Natural   Language Processing (NLP) in determining the Incidence of High Risk Breast Disease   and the Subsequent Development of Breast Cancer. Society   of Surgical Oncology 63rd Annual Cancer Symposium.
22.	Kim EMH, Sharko J, Drohan   B, Roche C, Specht M, Gadd M, Smith BL, Hughes KS, Breast cancer and high   risk diagnosis in core biopsies stratified by ethnicity. American Society of Clinical   Oncology, 2010.
23.	Kim EMH, Sharko J, Drohan B, Roche C, Specht   M, Gadd M, Smith BL, Hughes   KS, The utility of natural language processing (NLP)   in determining the incidence   of high risk breast disease and   the subsequent development of breast cancer. 63rd Annual   Meeting of the MGH Scientific Advisory Committee, 2010.
24.	Lin BK, Doksum TD, Edelman E, Edelson V, Carr B, McInerney   JA, Hughes KS, Drohan B, Sharko J,   O’Leary J, Kyler P, Puryear M, Dolan SM. Pilot testing an electronic,   point-of-care family health history tool for primary prenatal providers.  Presented at the 4th National Conference on   Genomics and Public Health, December 8, 2010.
25.	Coopey S, Smith BL, Hanson S, Buckley J, Hughes KS, Gadd M and Specht M.   “Multiple Re-Excisions after Lumpectomy – is it Safe?”  Abstract accepted for oral presentation at   the Society of Surgical Oncology’s Annual Cancer Symposium, March 2011.
26.	Lin BK, Edelman E, Doksum TD, Edelson V, Carr B, Dolan SM,   Hughes KS, Drohan B, O’Leary J,   Harris A, Puryear M, Scott JA. Satisfaction and perceived utility using an   electronic, point-of-care family health history tool among primary prenatal   providers and the public. Presented at the Annual Clinical Genetics Meeting   of theAmerican   College of Medical   Genetics, March 18, 2011.
27.	Edelman E, Lin BK, Edelson V, O’Leary J, Doksum T, Dolan   SM, Hughes KS, Drohan B, Harris A,   Lloyd-Puryear M, Scott JA.  Integrating   family health history, prenatal care, and patient education:  the Pregnancy and Health Profile.   Presentation at theSummit of theNew York –   Mid-Atlantic Consortium for Genetic and Newborn Screening Services, May 19,   2011.
28.	Drohan B,   Kelleher C, Grinstein G, Hughes KS. “Assessing Risks for   Families with Inherited Cancers”. Workshop on Visual Analytics in   Healthcare: Understanding the Physician Perspective.Rhode Island.  October   2011. (awaiting notification of acceptance)
29.	Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim   EMH, Polufriaginof F, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi   AJ, Roche CA, Hughes KS. Clarifying   the Risk of Breast Cancer in Women with Atypical Breast Lesions [abstract]. Cancer   Res; 71(24 Suppl.) December 15, 2011.
30.	Roche  CA, Hughes KS.   A Program to Increase Use of Chemoprevention for Women with High Risk Breast   Lesions. National Consortium of Breast   Centers 22nd Annual National Interdisciplinary Breast Center   Conference. Las Vegas,   NV. March, 2012.
31.	Wood, ME,   Kadlubek, Pam, Lu Karen, Weitzel J, Wollins D, Neuss Michael N, Hughes Kevin. Quality of Cancer   Family History and Referral for Genetic Counseling and Testing Among Oncology   Practices. A pilot testing of quality measures as part of the ASCO Quality   Oncology Practice Initiative (QOPI®). ASCO 2012, submitted as abstract
32.	Tang R,   Coopey SB, Buckley JM, Aftreth OP, Fernandez LJ, Brachtel EF, Michaelson JS,   Gadd MA, Specht MC, Hughes KS,   Koerner FC, Smith BL. Evaluation of Shaved Cavity Margins with Micro-Computed   Tomography—A Novel Method for Predicting Lumpectomy Margin Status   Intra-operatively. Abstract submitted for The American Society of Breast   Disease Annual Symposium, April 12-14, 2012,Dallas,TX.
33.	Biswas   S,  AtienzaP, ChipmanJ, AmosC,   HughesK, ArunB,   and Parmigiani G.A Two-Stage Approach to Genetic Risk   Prediction in Primary Care. University ofNorthTexas   HealthScience   Center Research   Appreciation Day, April 2012.
34.	Buckley JM,   Fernandez LJ, Brachtel EF, Aftreth OP, Tang R, Michaelson JS, Coopey SB, Gadd   MA, Specht MC, Hughes KS, Koerner   FC, Smith BL. The predictive value of micro-computed tomography for margin   assessment in breast cancer lumpectomy specimens. Abstract accepted for   Poster Presentation at the American Society of Breast Surgeons Annual   Meeting. May 2-6, 2012,Phoenix,  AZ. Abstract Number: 128.
35.	BiswasS, AtienzaP, ChipmanJ,   AmosC, HughesK,   ArunB, and Parmigiani G.A Two-Stage Approach to Genetic Risk Prediction in Primary Care.Joint   Statistical Meetings, July 2012.
36.	BiswasS,  AtienzaP, Chipman   J, AmosC, Hughes   K, ArunB, and Parmigiani G.A Two-Stage   Approach to Genetic Risk Prediction in Primary Care. Joint Statistical   Meetings, Aug 2012.
37.	Edelman E, Lin B, Doksum T, Drohan B, Hughes K, Dolan S, Edelson V, O’Leary J, Vasquez L, Copeland S   and Scott J. The Pregnancy and Health Profile Pilot Project: Evaluating the   impact of integrating a novel family history and genetic screening tool on   patients, providers, and clinical practice. American Society of Human Genetics   Annual Meeting, 2012.