by kshughes | Jul 4, 2016 | Blog
Here are some online knowledge bases that may be useful. General resources Public Health Genomics Knowledge Base (v1.0) https://phgkb.cdc.gov/GAPPKB/phgHome.do?action=about Genotype/Phenotype Phenopedia Enter phenotype and identify genetic/genomic relationships...
by kshughes | May 15, 2016 | Blog
Genetic panels look at a large number of genes, many of which have no relation to the phenotype of the patient. Mutations found in these genes are known as incidental findings. The genetics community is divided as to how best to manage these incidental findings, but...
by kshughes | Mar 15, 2016 | Gail
There is disagreement about this but the answer is normally no. The Gail model uses the number of biopsies as a surrogate for the presence of atypical hyperplasia. On the assumption that about 10% of biopsies will show AH, the Gail Model adds 10% of the risk of having...
by kshughes | Mar 15, 2016 | Surgery
Go to article and video...
by kshughes | Mar 3, 2016 | FAQ
Lifetime risk is very dependent on the age of the patient. An older patient with a lot of risk factors will have a lower lifetime risk than a younger patient with no risk. Percent of patients at lifetime risk of >=20% by decade. This shows that high lifetime...
by kshughes | Mar 3, 2016 | Guidelines, Lifetime Risk, Tyrer Cuzick
Yes. The intent of the guidelines was to look for younger women with a high long term risk, which is why they used lifetime risk. This means that older women with a high short term risk but a low lifetime risk are not eligible. MRI eligibility by age. Percent of...
by kshughes | Mar 3, 2016 | Gail
Hughes RiskApps runs the major models with a single data entry. The NCI tool is only the Gail model and is one of the models we run. Our results will essentially be the same with minor variations due to conventions adopted.
by kshughes | Mar 3, 2016 | Blog, Gail, Tyrer Cuzick
As the patient was 43 years old, then 13% would make sense as the average lifetime risk. Tyrer Cuzick and Gail are very different models and use different assumptions. Gail calculates risk of developing invasive breast cancer and Tyrer Cuzick calculates the risk of...
by kshughes | Mar 3, 2016 | Models
The Tyrer-Cuzick model does not have a strict minimum age for a calculation, although the per annum baseline risk for women under 30 is very small. This basically means that a woman essentially has the same lifetime risk at 20 as she does at 30 as long as the other...
by kshughes | Mar 3, 2016 | Boadicea, BRCAPRO, Claus, Guidelines, Tyrer Cuzick
NCCN guidelines recognize Tyrer Cuzick, Claus, BRCAPRO and Boadicea. Gail is not recognized as appropriate. National Comprehensive Cancer Network. Available The American Cancer Society (ACS) recognizes Tyrer Cuzick, Claus, and BRCAPRO. American Cancer Society in its...
