Knowledge bases for Genetics and Risk Assessment

Here are some online knowledge bases that may be useful. General resources Public Health Genomics Knowledge Base (v1.0) https://phgkb.cdc.gov/GAPPKB/phgHome.do?action=about Genotype/Phenotype Phenopedia Enter phenotype and identify genetic/genomic relationships...

Should a Core Biopsy be counted in the Gail model?

There is disagreement about this but the answer is normally no. The Gail model uses the number of biopsies as a surrogate for the presence of atypical hyperplasia. On the assumption that about 10% of biopsies will show AH, the Gail Model adds 10% of the risk of having...

NCCN and ACS guidelines support breast MRI >20% lifetime risk. So a woman has to beat the 20% threshold for lifetime risk as adjusted by her current age, correct?

Yes.  The intent of the guidelines was to look for younger women with a high long term risk, which is why they used lifetime risk.  This means that older women with a high short term risk but a low lifetime risk are not eligible. MRI eligibility by age.  Percent of...