Risk is defined in 2 ways:

  • Risk of mutation (If risk of mutation is 10% or greater consider genetic testing)
  • Risk of breast cancer (If lifetime risk of breast cancer is 20% or greater get an MRI)

4% of your population getting mammography will need genetic testing

For MRI, about 15% of your population will need an MRI based on the models.

If you use Tyrer Cuzick7, about 15% will need an MRI.

If you use Claus, about 0.9% will need an MRI.

If you use BRCAPRO, about 0.5% will need an MRI.

Tyrer Cuzick is really the driver of MRIs.

[ASCO_2014_NCCNB_BRCAPRO_TyrerCuzickRiskMutationsLifetimeRisk]

 

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